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Western Blot (WB) (Western blot analysis of extracts of various celllines, using PSRC1 antibody.)

anti-Human PSRC1 Antibody | anti-PSRC1 antibody

PSRC1 Antibody

Gene Names
PSRC1; DDA3; FP3214
Reactivity
Human
Applications
Western Blot, Immunohistochemistry
Purity
Immunogen affinity purified
Synonyms
PSRC1; PSRC1 Antibody; DDA3; FP3214; anti-PSRC1 antibody
Ordering
For Research Use Only!
Reactivity
Human
Specificity
PSRC1 Antibody detects endogenous levels of total PSRC1
Purity/Purification
Immunogen affinity purified
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Sequence Length
310
Applicable Applications for anti-PSRC1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
WB: 1:500-1:2000
IHC: 1:50-1:200
Immunogen
Recombinant protein of human PSRC1
Preparation and Storage
Store at-20 degree C for 1 year

Western Blot (WB)

(Western blot analysis of extracts of various celllines, using PSRC1 antibody.)

Western Blot (WB) (Western blot analysis of extracts of various celllines, using PSRC1 antibody.)
Related Product Information for anti-PSRC1 antibody
This gene encodes a proline-rich protein. Studies of this gene and the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. The encoded protein may function as a microtubule destabilizing protein that controls spindle dynamics and mitotic progression by recruiting and regulating microtubule depolymerases. At least one genetic variation in this gene has been associated with decreased serum levels of low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding different isoforms have been described.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
38kDa
NCBI Official Full Name
proline/serine-rich coiled-coil protein 1 isoform b
NCBI Official Synonym Full Names
proline and serine rich coiled-coil 1
NCBI Official Symbol
PSRC1
NCBI Official Synonym Symbols
DDA3; FP3214
NCBI Protein Information
proline/serine-rich coiled-coil protein 1
UniProt Protein Name
Proline/serine-rich coiled-coil protein 1
UniProt Gene Name
PSRC1
UniProt Synonym Gene Names
DDA3

NCBI Description

This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]

Uniprot Description

Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.

Research Articles on PSRC1

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Product Notes

The PSRC1 psrc1 (Catalog #AAA8516800) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The PSRC1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PSRC1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:2000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the PSRC1 psrc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PSRC1, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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