Rabbit anti-Human PSRC1 Polyclonal Antibody | anti-PSRC1 antibody

PSRC1 Antibody

Cat. Num. AAA9411601

• Gene Names: PSRC1; DDA3; FP3214
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: PSRC1; Polyclonal Antibody; PSRC1 Antibody; DDA3; FP3214; anti-PSRC1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total PSRC1 protein.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 310

• Applicable Applications for anti-PSRC1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:500 - 1:2000; Immunohistochemistry: 1:50 - 1:200
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human PSRC1.
• Target Name: PSRC1
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using PSRC1 antibody.)

Related Product Information for anti-PSRC1 antibody

This gene encodes a proline-rich protein. Studies of this gene and the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. The encoded protein may function as a microtubule destabilizing protein that controls spindle dynamics and mitotic progression by recruiting and regulating microtubule depolymerases. At least one genetic variation in this gene has been associated with decreased serum levels of low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding different isoforms have been described.

Product Categories/Family for anti-PSRC1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 52630338
• NCBI GeneID: 84722
• NCBI Accession #: NP_001005290.1
• NCBI GenBank Nucleotide #: NM_001005290.3
• UniProt Accession #: Q6PGN9; Q5T2Z3; Q6ZTI8; Q71MG3; Q9BV77
• Molecular Weight: 16,981 Da
• NCBI Official Full Name: proline/serine-rich coiled-coil protein 1 isoform b
• NCBI Official Synonym Full Names: proline/serine-rich coiled-coil 1
• NCBI Official Symbol: PSRC1
• NCBI Official Synonym Symbols: DDA3; FP3214
• NCBI Protein Information: proline/serine-rich coiled-coil protein 1
• UniProt Protein Name: Proline/serine-rich coiled-coil protein 1
• Protein Family: Proline/serine-rich coiled-coil protein
• UniProt Gene Name: PSRC1
• UniProt Synonym Gene Names: DDA3
• UniProt Entry Name: PSRC1_HUMAN

NCBI Description

This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]

Uniprot Description

PSRC1: Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. Belongs to the PSRC1 family. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: nucleoplasm; microtubule cytoskeleton; spindle pole; spindle microtubule; cytoplasm; spindle; midbody; cytosol

Molecular Function: protein binding; microtubule binding

Biological Process: positive regulation of cyclin-dependent protein kinase activity; cell division; positive regulation of transcription, DNA-dependent; positive regulation of microtubule polymerization; negative regulation of cell growth; mitotic metaphase plate congression; microtubule bundle formation