anti-Human PMS1 Antibody | anti-PMS1 antibody

PMS1 Antibody

Cat. Num. AAA8509838

• Gene Names: PMS1; MLH2; PMSL1; hPMS1; HNPCC3
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: PMS1; PMS1 Antibody; DNA mismatch repair protein PMS1; PMSL1; anti-PMS1 antibody

• Reactivity: Human
• Specificity: PMS1 antibody detects endogenous levels of total PMS1 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 932

• Applicable Applications for anti-PMS1 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50-1:100; ELISA: 1:10000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human PMS1.
• Preparation and Storage: Store at-20 degree C for 1 year.

Immunohistochemistry (IHC)

(Peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue using PMS1 antibody.)

References

Nicolaides N.C., Nature 371:75-80(1994). Rieder M.J., Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases. Wang Q., Hum. Genet. 105:79-85(1999).

NCBI and Uniprot Product Information

• NCBI GI #: 4505911
• NCBI GeneID: 5378
• NCBI Accession #: NP_000525.1
• NCBI GenBank Nucleotide #: NM_000534.4
• UniProt Accession #: P54277; Q4VAL4; Q5FBZ3; Q5FBZ6; Q5FBZ8; D3DPI1
• Molecular Weight: 62,919 Da
• NCBI Official Full Name: PMS1 protein homolog 1 isoform a
• NCBI Official Synonym Full Names: PMS1 homolog 1, mismatch repair system component
• NCBI Official Symbol: PMS1
• NCBI Official Synonym Symbols: MLH2; PMSL1; hPMS1; HNPCC3
• NCBI Protein Information: PMS1 protein homolog 1
• UniProt Protein Name: PMS1 protein homolog 1
• Protein Family: PMS1 protein
• UniProt Gene Name: PMS1
• UniProt Synonym Gene Names: PMSL1

NCBI Description

This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. [provided by RefSeq, Jul 2008]

Uniprot Description

Probably involved in the repair of mismatches in DNA.