anti-Human GFM2 Antibody | anti-GFM2 antibody

GFM2 Antibody

Cat. Num. AAA8514742

• Gene Names: GFM2; EFG2; RRF2; MRRF2; hEFG2; MST027; RRF2mt; EF-G2mt; MSTP027; mEF-G 2
• Reactivity: Human
• Applications: Western Blot, Immunofluorescence, Immunocytochemistry
• Purity: Immunogen affinity purified
• Synonyms: GFM2; GFM2 Antibody; EF-G 2; EFG2; elongation factor G 2; mitochondrial; elongation factor G2; G elongation factor; mitochondrial 2; anti-GFM2 antibody

• Reactivity: Human
• Specificity: GFM2 Antibody detects endogenous levels of total GFM2
• Purity/Purification: Immunogen affinity purified
• Form/Format: In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 811

• Applicable Applications for anti-GFM2 antibody: Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
• Application Notes: WB: 1:500~1:1000; IF/ICC: 1:100-1:500
• Immunogen: A synthesized peptide
• Preparation and Storage: Store at-20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of extracts from LOVO cells and RAW264.7cells, using GFM2 antibody)

NCBI and Uniprot Product Information

• NCBI GI #: 526479814
• NCBI GeneID: 84340
• NCBI Accession #: NP_001268231.1
• NCBI GenBank Nucleotide #: NM_001281302.1
• UniProt Accession #: Q969S9; Q8N6D8; Q8WYI0; Q9H6Z1; A0AR28
• Molecular Weight: 87 KD
• NCBI Official Full Name: ribosome-releasing factor 2, mitochondrial isoform 4
• NCBI Official Synonym Full Names: G elongation factor mitochondrial 2
• NCBI Official Symbol: GFM2
• NCBI Official Synonym Symbols: EFG2; RRF2; MRRF2; hEFG2; MST027; RRF2mt; EF-G2mt; MSTP027; mEF-G 2
• NCBI Protein Information: ribosome-releasing factor 2, mitochondrial
• UniProt Protein Name: Ribosome-releasing factor 2, mitochondrial
• UniProt Gene Name: GFM2
• UniProt Synonym Gene Names: hEFG2

NCBI Description

Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

Uniprot Description

Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.