sDLL4 active protein

sDLL4 protein

Cat. Num. AAA539451

• Gene Names: DLL4; hdelta2
• Applications: User optimized
• Purity: > 95% pure
• Synonyms: sDLL4; sDLL4 protein; sDLL-4 protein; sDLL 4 protein; sDLL 4; Delta-like protein 4; Drosophila Delta homolog 4 protein; sDLL-4; sDLL4 active protein

• Host: Human
• Purity/Purification: > 95% pure
• Form/Format: Supplied as a lyophilized powder.
• Sequence: Region of SDLL4 protein corresponding to amino acids SGVFQLQLQE FINERGVLAS GRPCEPGCRT FFRVCLKHFQ AVVSPGPCTF GTVSTPVLGT NSFAVRDDSS GGGRNPLQLP FNFTWPGTFS LIIEAWHAPG DDLRPEALPP DALISKIAIQ GSLAVGQNWL LDEQTSTLTR LRYSYRVICS DNYYGDNCSR LCKKRNDHFG HYVCQPDGNL SCLPGWTGEY CQQPICLSGC HEQNGYCSKP AECLCRPGWQ GRLCNECIPH NGCRHGTCST PWQCTCDEGW GGLFCDQDLN YCTHHSPCKN GATCSNSGQR SYTCTCRPGY TGVDCELELS ECDSNPCRNG GSCKDQEDGY HCLCPPGYYG LHCEHSTLSC ADSPCFNGGS CRERNQGANY ACECPPNFTG SNCEKKVDRC TSNPCANGGQ CLNRGPSRMC RCRPGFTGTY CELHVSDCAR NPCAHGGTCH DLENGLMCTC PAGFSGRRCE VRTSIDACAS SPCFNRATCY TDLSTDTFVC NCPYGFVGSR CEFPVGLP.
• Sequence Length: 685

• Applicable Applications for sDLL4 active protein: User optimized
• Protein Type: Recombinant
• Biological Significance: Human sDLL4 comprises the extracellular signaling domain of DLL, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. DLL4 functions to specifically activate the Notch-1 and Notch-4 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Targeted deletion of the DLL4 gene in mice resulted in severe vascular defects and death before birth.
• Bioactivity: The sDLL-4, when immobilized at concentrations >1.5 ug/mL will inhibit myogenesis in C2C12 cells.
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Expression System: 293 cells
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for sDLL4 active protein

Purified recombinant Human sDLL4 protein

Product Categories/Family for sDLL4 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 9506545
• NCBI GeneID: 54567
• NCBI Accession #: NP_061947.1
• NCBI GenBank Nucleotide #: NM_019074.3
• UniProt Accession #: Q9NR61; Q3KP23; Q9NQT9
• Molecular Weight: 54 kDa
• NCBI Official Full Name: delta-like protein 4
• NCBI Official Synonym Full Names: delta-like 4 (Drosophila)
• NCBI Official Symbol: DLL4
• NCBI Official Synonym Symbols: hdelta2
• NCBI Protein Information: delta-like protein 4
• UniProt Protein Name: Delta-like protein 4
• UniProt Gene Name: DLL4
• UniProt Synonym Gene Names: Delta4
• UniProt Entry Name: DLL4_HUMAN

NCBI Description

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]

Uniprot Description

DLL4: Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4. Binds to Notch-1 and Notch-4. Expressed in vascular endothelium.

Protein type: Membrane protein, integral; Cell development/differentiation

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: integral to membrane; plasma membrane

Molecular Function: calcium ion binding; Notch binding

Biological Process: patterning of blood vessels; negative regulation of cell proliferation; Notch signaling pathway; regulation of neurogenesis; visual perception; blood circulation; Notch receptor processing; blood vessel remodeling; negative regulation of transcription from RNA polymerase II promoter; angiogenesis; signal transduction