Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2) Recombinant Protein | HSPG2 recombinant protein

Recombinant Human Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2), partial

Cat. Num. AAA953064

• Gene Names: HSPG2; PLC; SJA; SJS; HSPG; SJS1; PRCAN
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2); Recombinant Human Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2); partial; HSPG2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 4197-4391. Partial
• Sequence: DAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVLHSARPGAPPPQPLDLQHRAQAGANTRPCPS

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 629266065
• NCBI GeneID: 3339
• NCBI Accession #: NP_001278789.1
• NCBI GenBank Nucleotide #: NM_001291860.1
• UniProt Accession #: P98160; Q16287; Q5SZI3; Q9H3V5
• Molecular Weight: 24.4
• NCBI Official Full Name: basement membrane-specific heparan sulfate proteoglycan core protein isoform a
• NCBI Official Synonym Full Names: heparan sulfate proteoglycan 2
• NCBI Official Symbol: HSPG2
• NCBI Official Synonym Symbols: PLC; SJA; SJS; HSPG; SJS1; PRCAN
• NCBI Protein Information: basement membrane-specific heparan sulfate proteoglycan core protein
• UniProt Protein Name: Basement membrane-specific heparan sulfate proteoglycan core protein
• Protein Family: Basement membrane-specific heparan sulfate proteoglycan core protein
• UniProt Gene Name: HSPG2
• UniProt Synonym Gene Names: HSPG; PLC

NCBI Description

This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

Uniprot Description

Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.