NCBI and Uniprot Product Information
NCBI Description
This gene encodes a type II transmembrane serine protease that may function in diverse processes, including regulation of cell growth. Deficiency in this gene results in hearing loss. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Uniprot Description
HPN: Plays an essential role in cell growth and maintenance of cell morphology. Belongs to the peptidase S1 family.
Protein type: EC 3.4.21.106; Membrane protein, integral; Protease
Cellular Component: cell soma; cell surface; endoplasmic reticulum membrane; integral to membrane; integral to plasma membrane; intercellular junction; membrane; nuclear membrane; plasma membrane
Molecular Function: calcium-activated potassium channel activity; hydrolase activity; peptidase activity; serine-type endopeptidase activity; serine-type peptidase activity
Biological Process: cholesterol homeostasis; detection of mechanical stimulus involved in sensory perception of sound; negative regulation of apoptosis; negative regulation of epithelial cell proliferation; positive regulation of cell growth; proteolysis; regulation of cell shape; sensory perception of sound
Research Articles on Hpn
Similar Products
Product Notes
The Mouse Hpn hpn (Catalog #AAA2887024) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2887024 ELISA Kit recognizes Mouse Hpn. It is sometimes possible for the material contained within the vial of "Serine protease hepsin, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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