E3 ubiquitin-protein ligase HOS1 (HOS1) Recombinant Protein | HOS1 recombinant protein

Recombinant Arabidopsis thaliana E3 ubiquitin-protein ligase HOS1 (HOS1) , partial

• Gene Names: HOS1; EARLY IN SHORT DAYS 6; ESD6; HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 1; T5I7.11; T5I7_11
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: E3 ubiquitin-protein ligase HOS1 (HOS1); Recombinant Arabidopsis thaliana E3 ubiquitin-protein ligase HOS1 (HOS1); partial; HOS1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 927

• Species: Arabidopsis thaliana (Mouse-ear cress)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 79571425
• NCBI GeneID: 818568
• NCBI Accession #: NP_181511.3
• NCBI GenBank Nucleotide #: NM_129540.5
• UniProt Accession #: Q84JU6; O22289
• Molecular Weight: 105,229 Da
• NCBI Official Full Name: ubiquitin-protein ligase
• NCBI Official Symbol: HOS1
• NCBI Official Synonym Symbols: EARLY IN SHORT DAYS 6; ESD6; HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 1; T5I7.11; T5I7_11
• NCBI Protein Information: ubiquitin-protein ligase
• UniProt Protein Name: E3 ubiquitin-protein ligase HOS1
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: HOS1

NCBI Description

A novel protein with a RING finger motif near the amino terminus. Negative regulator of cold responses. Functions as an E3 ligase required for the ubiquitination of ICE1. HOS1 physically interacts with ICE1 and mediates the ubiquitination of ICE1 both in vitro and in vivo. Overexpression represses the expression of CBFs and their downstream genes and confers increased sensitivity to freezing stress.

Uniprot Description

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of the transcription factor ICE1. Acts as a negative regulator of cold signaling pathways (PubMed:16702557). Probably involved in recruiting the NUP107-160 subcomplex of the nuclear pore complex to chromatin (Probable). Controls flowering time in response to ambient temperatures (16 and 23 degrees Celsius) and intermittent cold, probably via the regulation of FT and TSF levels (PubMed:22960247).