Horse Protein Arginine N-Methyltransferase 5 (PRMT5) ELISA Kit | PRMT5 elisa kit
Horse Protein Arginine N-Methyltransferase 5 (PRMT5) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Uniprot Description
PRMT5: an ubiquitous enzyme with protein methyltransferase activity. Methylates specific arginine residues in the transcription elongation factor SPT5, and the small nuclear ribonucleoproteins SNRPD1 and SNRPD3. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SPT5 transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Component of the methylosome, a 20S complex that includes ICLN, SKB1 and WDR77. Component of a high molecular weight E2F-pocket protein complex, CERC (cyclin E1 repressor complex). Also interacts with Sm proteins, JAK2, SSTR1 and SPT5. Associates with SWI/SNF remodeling complexes containing SMARCA2 and SMARCA4.
Protein type: Cell cycle regulation; Methyltransferase, protein arginine; Methyltransferase; RNA processing; EC 2.1.1.125
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: cytoplasm; cytosol; Golgi apparatus; histone methyltransferase complex; nucleoplasm; nucleus
Molecular Function: histone-arginine N-methyltransferase activity; methyl-CpG binding; methyltransferase activity; protein binding; protein complex binding; protein heterodimerization activity; protein-arginine N-methyltransferase activity; protein-arginine omega-N symmetric methyltransferase activity; ribonucleoprotein binding; transcription corepressor activity
Biological Process: cell proliferation; circadian regulation of gene expression; endothelial cell activation; establishment and/or maintenance of chromatin architecture; gene expression; negative regulation of cell differentiation; peptidyl-arginine methylation; peptidyl-arginine methylation, to symmetrical-dimethyl arginine; peptidyl-arginine N-methylation; positive regulation of oligodendrocyte differentiation; regulation of mitosis; regulation of transcription, DNA-dependent; spliceosomal snRNP biogenesis; transcription termination
Research Articles on PRMT5
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Product Notes
The Horse PRMT5 prmt5 (Catalog #AAA9364886) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9364886 ELISA Kit recognizes Horse PRMT5. It is sometimes possible for the material contained within the vial of "Protein Arginine N-Methyltransferase 5 (PRMT5), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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