SDS-Page
(Fig.SDS-PAGE analysis of Mouse GM-CSF protei.)
GM-CSF recombinant protein
Mouse GM-CSF protein
Gene Names
Csf2; Csfgm; GMCSF; Gm-CSf; MGI-IGM
Purity
>=90 % as determined by SDS-PAGE
Synonyms
GM-CSF; Mouse GM-CSF protein; CSF; CSF2; CSF-2; GMCSF; colony stimulating factor 2 (granulocyte-macrophage); granulocyte-macrophage colony-stimulating factor; Colony-stimulating factor; granulocyte-macrophage colony stimulating factor; molgramostin; Sargramostim; MGC131935; MGC138898; Molgramostim; GM-CSF recombinant protein
Host
HEK293 Cells
Purity/Purification
>=90 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH7.4.
Tag
GM-CSF
Protein Construction
The recombinant Mouse GM-CSF protein consists of 128 amino acids and has a predicted molecular mass of 14.6kDa. The apparent molecular mass of the Mouse GM-CSF protein is approximately 15-25kDa in SDS-PAGE under reducing conditions.
Amino acid sequence derived from Mouse GM-CSF protein isoform (P01587, Met1-Lys141) was expressed.
Amino acid sequence derived from Mouse GM-CSF protein isoform (P01587, Met1-Lys141) was expressed.
Usage Notes
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Mouse GM-CSF protein using the buffer we provided not less than 100 ug/mL, which can then be further diluted to other aqueous solutions.
Preparation and Storage
Lyophilized Mouse GM-CSF proteinshould be stored desiccated below -20 degree C. Upon reconstitution, the protein should be Store at 4 degree C between 2-7 days and for future use below -20 degree C. For long term storage it is recommended to add a carrier protein (0.130% HSA or BSA). Please prevent freeze-thaw cycles.
Shipping||The product is shipped at ambient temperature.
Shipping||The product is shipped at ambient temperature.
SDS-Page
(Fig.SDS-PAGE analysis of Mouse GM-CSF protei.)
SDS-Page
(Fig.SDS-PAGE analysis of Mouse GM-CSF protei.)
Related Product Information for GM-CSF recombinant protein
Description: Mouse GM-CSF protein, expressed in HEK293 Cells
Background: The granulocyte-macrophage colony-stimulating factor (GM-CSF) is an important hematopoietic growth factor and immune modulator. GM-CSF also has profound effects on the functional activities of various circulating leukocytes. It is produced by a variety of cell types including T cells, macrophages, endothelial cells and fibroblasts upon receiving immune stimuli. Although GM-CSF is produced locally, it can act in a paracrine fashion to recruit circulating neutrophils, monocytes and lymphocytes to enhance their functions in host defense. GM-CSF was initially classified as a hematopoietic growth factor. However, unlike its close relatives macrophage CSF (M-CSF) and granulocyte CSF (G-CSF), the majority of myeloid cells do not require GM-CSF for steady-state myelopoiesis. Instead, in inflammation, GM-CSF serves as a communication conduit between tissue-invading lymphocytes and myeloid cells. Even though lymphocytes are in all likelihood the instigators of chronic inflammatory disease, GM-CSF-activated phagocytes are well equipped to cause tissue damage.
Background: The granulocyte-macrophage colony-stimulating factor (GM-CSF) is an important hematopoietic growth factor and immune modulator. GM-CSF also has profound effects on the functional activities of various circulating leukocytes. It is produced by a variety of cell types including T cells, macrophages, endothelial cells and fibroblasts upon receiving immune stimuli. Although GM-CSF is produced locally, it can act in a paracrine fashion to recruit circulating neutrophils, monocytes and lymphocytes to enhance their functions in host defense. GM-CSF was initially classified as a hematopoietic growth factor. However, unlike its close relatives macrophage CSF (M-CSF) and granulocyte CSF (G-CSF), the majority of myeloid cells do not require GM-CSF for steady-state myelopoiesis. Instead, in inflammation, GM-CSF serves as a communication conduit between tissue-invading lymphocytes and myeloid cells. Even though lymphocytes are in all likelihood the instigators of chronic inflammatory disease, GM-CSF-activated phagocytes are well equipped to cause tissue damage.
Product Categories/Family for GM-CSF recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
16,091 Da
NCBI Official Full Name
granulocyte-macrophage colony-stimulating factor
NCBI Official Synonym Full Names
colony stimulating factor 2 (granulocyte-macrophage)
NCBI Official Symbol
Csf2
NCBI Official Synonym Symbols
Csfgm; GMCSF; Gm-CSf; MGI-IGM
NCBI Protein Information
granulocyte-macrophage colony-stimulating factor; CSF; granulocyte-macrophage colony stimulating factor 2; put. GM-CSF
UniProt Protein Name
Granulocyte-macrophage colony-stimulating factor
UniProt Gene Name
Csf2
UniProt Synonym Gene Names
Csfgm; GM-CSF; CSF
UniProt Entry Name
CSF2_MOUSE
Uniprot Description
GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family.
Protein type: Secreted; Cytokine; Secreted, signal peptide
Cellular Component: extracellular space; extracellular region
Molecular Function: growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity
Biological Process: negative regulation of cytolysis; epithelial fluid transport; embryonic placenta development; macrophage activation; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of gene expression; positive regulation of interleukin-23 production; positive regulation of cell proliferation; myeloid dendritic cell differentiation; immune response; positive regulation of DNA replication; regulation of cell proliferation
Research Articles on GM-CSF
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Product Notes
The GM-CSF csf2 (Catalog #AAA9719250) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GM-CSF, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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