Heterogeneous nuclear ribonucleoprotein L (Hnrnpl) Recombinant Protein | Hnrnpl recombinant protein

Recombinant Mouse Heterogeneous nuclear ribonucleoprotein L (Hnrnpl)

Cat. Num. AAA1425316

• Gene Names: Hnrnpl; Hnrpl; C79783; D830027H13Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Heterogeneous nuclear ribonucleoprotein L (Hnrnpl); Recombinant Mouse Heterogeneous nuclear ribonucleoprotein L (Hnrnpl); Hnrnpl recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-586, Full length protein
• Sequence: MSRRLLPRAEKRRRRLEQRQQPDEQLRRAGAMVKMAAAGGGGGGGRYYGGGNEGGRAPKRLKTENAGDQHGGGGGGGSGAAGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPDYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKMNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPTSVKVFSGKSERSSSGLLEWDSKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS
• Sequence Length: 586

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Hnrnpl recombinant protein

Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 183980004
• NCBI GeneID: 15388
• NCBI Accession #: NP_796275.3
• NCBI GenBank Nucleotide #: NM_177301.5
• UniProt Accession #: Q8R081; O54789; Q499X2; Q8K0S7
• Molecular Weight: 63,964 Da
• NCBI Official Full Name: heterogeneous nuclear ribonucleoprotein L
• NCBI Official Synonym Full Names: heterogeneous nuclear ribonucleoprotein L
• NCBI Official Symbol: Hnrnpl
• NCBI Official Synonym Symbols: Hnrpl; C79783; D830027H13Rik
• NCBI Protein Information: heterogeneous nuclear ribonucleoprotein L
• UniProt Protein Name: Heterogeneous nuclear ribonucleoprotein L
• Protein Family: Heterogeneous nuclear ribonucleoprotein
• UniProt Gene Name: Hnrnpl
• UniProt Synonym Gene Names: Hnrpl; hnRNP L

Uniprot Description

Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion (PubMed:22523384). Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.