Heterogeneous Nuclear Ribonucleoprotein C Recombinant Protein | HNRNPC recombinant protein

Recombinant Human Heterogeneous Nuclear Ribonucleoprotein C

Cat. Num. AAA145347

• Gene Names: HNRNPC; C1; C2; HNRNP; HNRPC; SNRPC
• Purity: Greater than 85% as determined by SDS-PAGE.
• Synonyms: Heterogeneous Nuclear Ribonucleoprotein C; Recombinant Human Heterogeneous Nuclear Ribonucleoprotein C; HNRNPC Human; Heterogeneous Nuclear Ribonucleoprotein C Human Recombinant; Heterogeneous Nuclear Ribonucleoprotein C (C1/C2); HNRPC; hnRNP C1/C2; hnRNPC; C1; C2; SNRPC; MGC104306; MGC105117; MGC117353; MGC131677; HNRNPC recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 85% as determined by SDS-PAGE.
• Form/Format: The HNRNPC protein solution (0.25mg/ml) is formulated in 20mM Tris-HCl buffer (pH8.0), 200mM NaCl, 5mM DTT and 30% glycerol.; Sterile Filtered clear solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MASNVTNKTD PRSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIVGCSVHK GFAFVQYVNE RNARAAVAGE DGRMIAGQVL DINLAAEPKV NRGKAGVKRS AAEMYGSSFD LDYDFQRDYY DRMYSYPARV PPPPPIARAV VPSKRQRVSG NTSRRGKSGF NSKSGQRGSS KSGKLKGDDL QAIKKELTQI KQKVDSLLEN LEKIEKEQSK QAVEMKNDKS EEEQSSSSVK KDETNVKMES EGGADDSAEE GDLLDDDDNE DRGDDQLELI KDDEKEAEEG EDDRDSANGE DDS
• Sequence Length: 306

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for HNRNPC recombinant protein

Description: HNRNPC produced in E Coli is a single, non-glycosylated polypeptide chain containing 313 amino acids (1-293a.a.) and having a molecular mass of 34.5kDa (Molecular weight on SDS-PAGE will appear higher). HNRNPC is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: HNRNPC is a member of the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) which are related to pre mRNAs in the nucleus and effect pre mRNA processing and other aspects of mRNA metabolism and transport. Although all of the hnRNPs are present in the nucleus, several hnRNPs travel between the nucleus and the cytoplasm. The hnRNP proteins have specific nucleic acid binding properties.

Product Categories/Family for HNRNPC recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Heterogeneous Nuclear Ribonucleoprotein

NCBI and Uniprot Product Information

• NCBI GI #: 117190192
• NCBI GeneID: 3183
• NCBI Accession #: NP_001070910.1
• NCBI GenBank Nucleotide #: NM_001077442.1
• UniProt Accession #: P07910; P22628; Q53EX2; Q59FD3; Q5FWE8; Q86SF8; Q86U45; Q96HK7; Q96HM4; Q96IY5; D3DS19; D3DS22
• Molecular Weight: 27,822 Da
• NCBI Official Full Name: heterogeneous nuclear ribonucleoproteins C1/C2 isoform a
• NCBI Official Synonym Full Names: heterogeneous nuclear ribonucleoprotein C (C1/C2)
• NCBI Official Symbol: HNRNPC
• NCBI Official Synonym Symbols: C1; C2; HNRNP; HNRPC; SNRPC
• NCBI Protein Information: heterogeneous nuclear ribonucleoproteins C1/C2; hnRNP C1/C2; nuclear ribonucleoprotein particle C1 protein; nuclear ribonucleoprotein particle C2 protein
• UniProt Protein Name: Heterogeneous nuclear ribonucleoproteins C1/C2
• Protein Family: Heterogeneous nuclear ribonucleoprotein
• UniProt Gene Name: HNRNPC
• UniProt Synonym Gene Names: HNRPC; hnRNP C1/C2
• UniProt Entry Name: HNRPC_HUMAN

NCBI Description

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

hnRNP C1/C2: a heterogeneous nuclear ribonucleoprotein. May play a role in ribonucleosome assembly by neutralizing basic proteins such as A and B core hnRNP. Contains 1 RNA recognition motif (RRM) domain. Two alternatively spliced isoforms have been described.

Protein type: RNA-binding; Spliceosome; RNA splicing

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: nucleoplasm; spliceosome; protein complex; membrane; nuclear chromatin; nucleus; cytosol

Molecular Function: identical protein binding; protein binding; nucleosomal DNA binding; mRNA 3'-UTR binding; RNA binding; nucleotide binding; poly(U) binding

Biological Process: osteoblast differentiation; nuclear mRNA splicing, via spliceosome; RNA splicing; ATP-dependent chromatin remodeling; gene expression