Human High mobility group protein HMG-I/HMG-Y ELISA Kit | HMGA1 elisa kit

Human High mobility group protein HMG-I/HMG-Y ELISA Kit

Cat. Num. AAA2880846

• Gene Names: HMGA1; HMG-R; HMGIY; HMGA1A
• Reactivity: Human
• Synonyms: High mobility group protein HMG-I/HMG-Y; Human High mobility group protein HMG-I/HMG-Y ELISA Kit; HMG-I(Y); High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein R; HMGA1; HMGIY; HMGA1 elisa kit

• Reactivity: Human
• Sequence Length: 96

• Assay Type: Sandwich
• Detection Range: 0.156-10 ng/ml
• Sensitivity: 0.039 ng/mL
• Intra-Assay CV: <=4.1%
• Inter-Assay CV: <=7.2%
• Recovery: 84%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 4504433
• NCBI GeneID: 3159
• NCBI Accession #: NP_002122.1
• NCBI GenBank Nucleotide #: NM_002131.3
• UniProt Accession #: P17096; P10910; Q5T6U9; Q9UKB0
• Molecular Weight: 19,694 Da
• NCBI Official Full Name: high mobility group protein HMG-I/HMG-Y isoform b
• NCBI Official Synonym Full Names: high mobility group AT-hook 1
• NCBI Official Symbol: HMGA1
• NCBI Official Synonym Symbols: HMG-R; HMGIY; HMGA1A
• NCBI Protein Information: high mobility group protein HMG-I/HMG-Y
• UniProt Protein Name: High mobility group protein HMG-I/HMG-Y
• Protein Family: High mobility group protein
• UniProt Gene Name: HMGA1
• UniProt Synonym Gene Names: HMGIY; HMG-I(Y); High mobility group protein A1
• UniProt Entry Name: HMGA1_HUMAN

NCBI Description

This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]

Uniprot Description

HMGA1: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B. Belongs to the HMGA family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: cytosol; focal adhesion; nucleoplasm; nucleus; transcription factor complex

Molecular Function: 5'-deoxyribose-5-phosphate lyase activity; AT DNA binding; chromatin binding; DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; enzyme binding; ligand-dependent nuclear receptor transcription coactivator activity; peroxisome proliferator activated receptor binding; protein binding; retinoic acid receptor binding; retinoid X receptor binding; transcription factor activity; transcription factor binding

Biological Process: base-excision repair; DNA unwinding during replication; negative regulation of cell proliferation; negative regulation of chromatin silencing; negative regulation of transcription, DNA-dependent; nucleosome disassembly; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein complex assembly; regulation of transcription, DNA-dependent; response to virus; transcription from RNA polymerase II promoter; viral reproduction