Major Histocompatibility Complex Class I C Recombinant Protein | HLA-C recombinant protein

Recombinant Human Major Histocompatibility Complex Class I C

Cat. Num. AAA146106

• Gene Names: HLA-C; HLC-C; D6S204; PSORS1; HLA-JY3
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Major Histocompatibility Complex Class I C; Recombinant Human Major Histocompatibility Complex Class I C; HLA-C Human; Major Histocompatibility Complex Class I C Human Recombinant; Major Histocompatibility Complex Class I- C; D6S204; HLA-JY3; PSORS1; HLC-C; HLA Class I Histocompatibility Antigen C Alpha Chain; Human Leukocyte Antigen-C Alpha Chain; Major Histocompatibility Antigen HLA-C; MHC Class I Antigen Heavy Chain HLA-C; HLA-C recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: The HLA-C solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 20% glycerol.; Sterile Filtered clear solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSCSHSMRY FDTAVSRPGR GEPRFISVGY VDDTQFVRFD SDAASPRGEP RAPWVEQEGP EYWDRETQKY KRQAQADRVS LRNLRGYYNQ SEDGSHTLQR MSGCDLGPDG RLLRGYDQSA YDGKDYIALN EDLRSWTAAD TAAQITQRKL EAARAAEQLR AYLEGTCVEW LRRYLENGKE TLQRAEPPKT HVTHHPLSDH EATLRCWALG FYPAEITLTW QRDGEDQTQD TELVETRPAG DGTFQKWAAV VVPSGQEQRY TCHMQHEGLQ EPLTLSWEPS SQPTIPI
• Sequence Length: 366

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks.; Store, frozen at -20 degree C for longer periods of time ; For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Related Product Information for HLA-C recombinant protein

Description: HLA-C Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 307 amino acids (25-308) and having a molecular mass of 34.9kDa.HLA-C is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Major Histocompatibility Complex Class I C (HLA-C) belongs to the HLA class I heavy chain paralogues. The HLA-C (class I molecule) is a heterodimer comprised of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules have a key role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. Class I molecules are expressed in virtually all cells.

Product Categories/Family for HLA-C recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Major Histocompatibility Complex

NCBI and Uniprot Product Information

• NCBI GI #: 52630342
• NCBI GeneID: 3107
• NCBI Accession #: NP_002108
• NCBI GenBank Nucleotide #: NM_002117.5
• Molecular Weight: 40,861 Da
• NCBI Official Full Name: HLA class I histocompatibility antigen, Cw-1 alpha chain
• NCBI Official Synonym Full Names: major histocompatibility complex, class I, C
• NCBI Official Symbol: HLA-C
• NCBI Official Synonym Symbols: HLC-C; D6S204; PSORS1; HLA-JY3
• NCBI Protein Information: HLA class I histocompatibility antigen, Cw-1 alpha chain; HLA class I histocompatibility antigen, C alpha chain; MHC class I antigen heavy chain HLA-C; human leukocyte antigen-C alpha chain; major histocompatibility antigen HLA-C
• UniProt Protein Name: HLA class I histocompatibility antigen, Cw-3 alpha chain
• Protein Family: HLA class I histocompatibility antigen
• UniProt Gene Name: HLA-C
• UniProt Synonym Gene Names: HLAC
• UniProt Entry Name: 1C03_HUMAN

NCBI Description

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008]

Uniprot Description

HLAC iso7: Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: Golgi membrane; Golgi apparatus; phagocytic vesicle membrane; cell surface; early endosome membrane; endoplasmic reticulum; integral to plasma membrane; plasma membrane; extracellular region; MHC class I protein complex

Molecular Function: peptide antigen binding; TAP binding; receptor binding

Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of peptide antigen via MHC class I; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; immune response