IL7Ra/CD127 Active Protein | IL17Ra active protein

Human CellExp IL7Ra / CD127, human recombinant

Cat. Num. AAA844402

• Gene Names: IL17RA; CD217; IL17R; CANDF5; CDw217; IL-17RA; hIL-17R
• Applications: SDS-Page
• Purity: >=95%
• Synonyms: IL7Ra/CD127; Human CellExp IL7Ra / CD127; human recombinant; IL7Ra; CD127; IL17Ra active protein

• Host: HEK293 cells
• Purity/Purification: >=95%
• Form/Format: Lyophilized from 0.22 mum filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.; Appearance: Lyophilized
• Sequence Length: 832

• Applicable Applications for IL17Ra active protein: SDS-PAGE
• Solubility/Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 month. For extended storage, it is recommended to store at -20 degree C.
• Endotoxin Level: <1 EU/mug by LAL method
• Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized rhIL7Ra Fc Chimera at 0.25 mug/ml (100 mul/well) on a Rabbit anti?human IgG Fc antibody, the concentration of rhIL-7 that produces 50% of the optimal binding response is found to be approximately 20 - 100 ng/mL.
• Results: Measured by its binding ability in a functional ELISA. Immobilized rhIL7Ra Fc Chimera at 0.25 mug/ml (100 mul/well) on a Rabbit anti?human IgG Fc antibody, the concentration of rhIL-7 that produces 50% of the optimal binding response is found to be approximately 20 - 100 ng/mL.
• Handling: Centrifuge the vial prior to opening.
• Preparation and Storage: At -20 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for IL17Ra active protein

Background: Interleukin-7 receptor subunit alpha (IL7Ra) also known as CD antigen CD127, which belongs to the type I cytokine receptor family and type 4 subfamily. IL7Ra /CD127 contains 1 fibronectin type-III domain. IL7Ra /CD127 is expressed on various cell types, including naive and memory T cells and many others. IL7Ra /CD127 is receptor for interleukin-7 and also acts as a receptor for thymic stromal lymphopoietin (TSLP). The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

Product Categories/Family for IL17Ra active protein

Cytokines; Growth Factors & Hormones; Human cell expressed recombinant proteins Proteins and Enzymes; Human cell expressed recombinant proteins Cytokines; Growth Factors & Hormones; InterleukinsProteins and Enzymes; Cytokines; Growth Factors & Hormones; C

NCBI and Uniprot Product Information

• NCBI GI #: 583966138
• NCBI GeneID: 23765
• NCBI Accession #: NP_001276834.1
• NCBI GenBank Nucleotide #: NM_001289905.1
• UniProt Accession #: Q96F46; O43844; Q20WK1
• Molecular Weight: This protein is fused with Fc fragment of human IgG1 at the C-terminus, has a calculated MW of 51 kDa. The predicted N-terminus is Glu 21. DTT-reduced Protein migrates as 66-90 kDa due to glycosylation.
• NCBI Official Full Name: interleukin-17 receptor A isoform 2
• NCBI Official Synonym Full Names: interleukin 17 receptor A
• NCBI Official Symbol: IL17RA
• NCBI Official Synonym Symbols: CD217; IL17R; CANDF5; CDw217; IL-17RA; hIL-17R
• NCBI Protein Information: interleukin-17 receptor A
• UniProt Protein Name: Interleukin-17 receptor A
• Protein Family: Interleukin-17 receptor
• UniProt Gene Name: IL17RA
• UniProt Synonym Gene Names: IL17R; IL-17 receptor A; IL-17RA
• UniProt Entry Name: I17RA_HUMAN

NCBI Description

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

Uniprot Description

IL17RA: Receptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. Widely expressed.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 22q11.1

Cellular Component: integral to plasma membrane; extracellular region

Molecular Function: protein binding; interleukin-17 receptor activity

Biological Process: cell surface receptor linked signal transduction; positive regulation of interleukin-23 production; cytokine and chemokine mediated signaling pathway

Disease: Candidiasis, Familial, 5