SR-BI/SCARB1 Cell Lysate | SCARB1 cell lysate
Mouse SR-BI/SCARB1 HEK293 Overexpression Lysate
Modified RIPA Lysis Buffer: 50 mM Tris-HCl pH 7.4, 150 mM NaCl, 1mM EDTA, 1% Triton X-100, 0.1% SDS, 1% Sodium deoxycholate, 1mM PMSF.
Samples are stable for up to twelve months from date of receipt.
This Mouse SR-BI/SCARB1 overexpression lysate was created in HEK293 Cells and intented for use as a Western blot (WB) positive control. Purification of SR-BI/SCARB1 protein from the overexpression lysate was verified.
NCBI and Uniprot Product Information
Uniprot Description
SCARB1: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester. Belongs to the CD36 family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, misc.
Cellular Component: caveola; cell surface; cytoplasm; integral to membrane; integral to plasma membrane; intracellular membrane-bound organelle; lysosomal membrane; membrane; microvillus membrane; plasma membrane
Molecular Function: apolipoprotein A-I binding; apolipoprotein binding; high-density lipoprotein binding; lipopolysaccharide binding; lipopolysaccharide receptor activity; low-density lipoprotein binding; phosphatidylserine binding; protein homodimerization activity
Biological Process: adhesion to host; androgen biosynthetic process; blood vessel endothelial cell migration; cholesterol catabolic process; cholesterol efflux; cholesterol homeostasis; cholesterol transport; detection of lipopolysaccharide; endothelial cell proliferation; intestinal absorption; lipid transport; lipopolysaccharide transport; lipopolysaccharide-mediated signaling pathway; phagocytosis, recognition; phospholipid transport; positive regulation of nitric-oxide synthase activity; recognition of apoptotic cell; regulation of phagocytosis; reverse cholesterol transport
Research Articles on SCARB1
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Product Notes
The SCARB1 scarb1 (Catalog #AAA8116535) is a Cell Lysate produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 419aa. AAA Biotech's SR-BI/SCARB1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: Use at an assay dependent dilution. Researchers should empirically determine the suitability of the SCARB1 scarb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Pro33-Val4 40. It is sometimes possible for the material contained within the vial of "SR-BI/SCARB1, Cell Lysate" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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