CD200R Active Protein | CD200R1 active protein

CD200R Protein, Human, Recombinant (His & hFc Tag)

Cat. Num. AAA8120741

• Gene Names: CD200R1; OX2R; MOX2R; CD200R; HCRTR2
• Purity: >94% as determined by SDS-PAGE
• Synonyms: CD200R; CD200R Protein; Human; Recombinant (His & hFc Tag); Human CD200R1 Protein (His & Fc Tag); HCRTR2 Protein; MOX2R Protein; OX2R Protein; CD200 receptor 1; CD200R1 active protein

• Host: HEK293 Cells
• Purity/Purification: >94% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Leu266

• Species: Human
• Activity: Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD200 at 1ug/ml (100ul/well) can bind human CD200R1/Fc Chimera with a linear range of 0.12-16ng/mL.
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Ala 27
• Tag: C-human IgG1-Fc & His
• Protein Construction: A DNA sequence encoding the human CD200R1 (AAI43394.1) extracellular doamin (Met 1-Leu 266) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Testing Data

(Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD200 at 1 ug/ml (100 ul/well) can bind human CD200R1 / Fc Chimera with a linear range of 0.12-16 ng/ml.)

Related Product Information for CD200R1 active protein

Background: The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cell surface glycoprotein CD200 receptor 1 (CD200R1) is an isoform of CD200 receptors that is expressed on cells of the myeloid lineage. CD200R1 is a receptor for the OX-2 membrane glycoprotein. The receptor-substrate interaction may serve as a myeloid downregulatory signal.

Product Categories/Family for CD200R1 active protein

Neuroinflammation Cancer Drug Targets

References

Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.

NCBI and Uniprot Product Information

• NCBI GI #: 219519975
• NCBI GeneID: 131450
• Molecular Weight: 39,056 Da
• NCBI Official Full Name: CD200R1 protein
• NCBI Official Synonym Full Names: CD200 receptor 1
• NCBI Official Symbol: CD200R1
• NCBI Official Synonym Symbols: OX2R; MOX2R; CD200R; HCRTR2
• NCBI Protein Information: cell surface glycoprotein CD200 receptor 1
• Protein Family: Cell surface glycoprotein CD200 receptor

NCBI Description

This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]