CD200R1 / CD200R recombinant protein

Recombinant Human CD200R1 / CD200R Protein (His tag)

Cat. Num. AAA2545860

• Gene Names: CD200R1; OX2R; MOX2R; CD200R; HCRTR2
• Purity: > 98 % as determined by SDS-PAGE
• Synonyms: CD200R1 / CD200R; Recombinant Human CD200R1 / CD200R Protein (His tag); CD200R; HCRTR2; MOX2R; OX2R; CD200R1; CD200R1 / CD200R recombinant protein

• Host: Human Cells
• Purity/Purification: > 98 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 348

• Application Notes: The secreted recombinant human CD200R1 comprises 251 amino acids after removal of the signal peptide and has a predicted molecular mass of 28.2 kDa. As a result of glycosylation, rh CD200R1 migrates as an approximately 50-60 kDa band in SDS-PAGE under reducing conditions.
• Predicted N Terminal: Ala 27
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for CD200R1 / CD200R recombinant protein

Background: The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cell surface glycoprotein CD200 receptor 1 (CD200R1) is an isoform of CD200 receptors which is expressed on cells of the myeloid lineage. CD200R1 is a receptor for the OX-2 membrane glycoprotein. The receptor-substrate interaction may serve as a myeloid downregulatory signal.

Description: A DNA sequence encoding the human CD200R1 (AAI43394.1) extracellular domain (Met 1-Leu 266) was fused with a polyhistidine tag at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 219519975
• NCBI GeneID: 131450
• Molecular Weight: 39,056 Da
• NCBI Official Full Name: CD200R1 protein
• NCBI Official Synonym Full Names: CD200 receptor 1
• NCBI Official Symbol: CD200R1
• NCBI Official Synonym Symbols: OX2R; MOX2R; CD200R; HCRTR2
• NCBI Protein Information: cell surface glycoprotein CD200 receptor 1
• UniProt Protein Name: Cell surface glycoprotein CD200 receptor 1
• UniProt Gene Name: CD200R1
• UniProt Synonym Gene Names: CD200R; CRTR2; MOX2R; OX2R

NCBI Description

This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Description

CD200R: Receptor for the CD200/OX2 cell surface glycoprotein. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. Belongs to the CD200R family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 3q13.2

Cellular Component: external side of plasma membrane; plasma membrane; receptor complex

Molecular Function: protein binding; receptor activity

Biological Process: regulation of immune response