SDS-Page
Her2/ErbB2, Cynomolgus Active Protein | ErbB2 active protein
Human CellExp Her2/ErbB2, Cynomolgus Recombinant
Purity
>=95% by SDS-PAGE
Synonyms
Her2/ErbB2; Cynomolgus; Human CellExp Her2/ErbB2; Cynomolgus Recombinant; ERBB2; CD340; HER-2/neu; HER2; MLN19; NEU; NGL; TKR1; ErbB2 active protein
Host
HEK293 cells
Purity/Purification
>=95% by SDS-PAGE
Form/Format
Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Generally Trehalose is added as a protectant before lyophilization.
Gene Source
Cynomolgus
Endotoxin
<1 EU/ug by LAL method
Biological Activity
Immobilized Trastuzumab at 2 ug/mL (100 uL/well) can bind Cynomolgus Her2 with a linear range of 2-6 ng/mL
Measured by its binding ability in a functional ELISA.
Measured by its binding ability in a functional ELISA.
Reconstitution Instruction
Reconstitute in sterile deionized water to a concentration of 50 ug/ml.
Preparation and Storage
Store at -20 degree C
Centrifuge the vial prior to opening.
Shelf life: ~12 months
Centrifuge the vial prior to opening.
Shelf life: ~12 months
SDS-Page
SDS-Page
Testing Data
Testing Data
Related Product Information for ErbB2 active protein
Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2, HER-2 /neu, NEU, NGL, TKR1 and c-erb B2, and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation.
Product Categories/Family for ErbB2 active protein
NCBI and Uniprot Product Information
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Product Notes
The ErbB2 (Catalog #AAA849971) is an Active Protein produced from HEK293 cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Her2/ErbB2, Cynomolgus, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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