NKp46/NCR1 Active Protein | NCR1 active protein

NKp46/NCR1 Protein, Mouse, Recombinant (ECD, His Tag)

Cat. Num. AAA8122925

• Gene Names: Ncr1; Ly94; NKp46
• Purity: >95% as determined by SDS-PAGE
• Synonyms: NKp46/NCR1; NKp46/NCR1 Protein; Mouse; Recombinant (ECD; His Tag); Mouse NCR1/NK-p46 Protein (His Tag); Ly94 Protein; NKp46 Protein; natural cytotoxicity triggering receptor 1; NCR1 active protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Asn255

• Species: Mouse
• Activity: Measured by its ability to bind with recombinant human CD247/Biotin in a functional ELISA.
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Gln 17
• Tag: C-His
• Protein Construction: A DNA sequence encoding the mouse NCR1 (NP_034876.2)(Met1-Asn255) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for NCR1 active protein

Background: NCR1, also known as NK-p46 and CD335, is a natural cytotoxicity receptor(NCR). NCRs are type I transmembrane proteins with 1-2 extracellular immunoglobulin domains, a transmembrane domain containing a positively charged amino acid residue, and a short cytoplasmic tail. All are expressed almost exclusively by NK cells and play a major role in triggering NK-mediated killing of most tumor cell lines. NKp46 has two extracellular Ig-like domains followed by a ~40 residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells, pathogen-infected cell lines, and mononuclear phagocytes infected with an intracellular bacterium.

Product Categories/Family for NCR1 active protein

ITIM/ITAM Immunoreceptors and Related Molecules

References

Carbone E, et al. (2005) HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells. Blood. 105(1):251-8.Sivori S, et al. (1997) p46, a Novel Natural Killer Cell-specific Surface Molecule That Mediates Cell Activation. J Exp Med. 186(7):1129-36.Biassoni R, et al. (2004) Human natural killer cell receptors: insights into their molecular function and structure. J Cell Mol Med. 7(4):376-87.

NCBI and Uniprot Product Information

• NCBI GI #: 31981638
• NCBI GeneID: 17086
• NCBI Accession #: NP_034876.2
• NCBI GenBank Nucleotide #: NM_010746.3
• UniProt Accession #: Q8C567; Q1RLN4; Q80UY6; Q9Z0Q4
• Molecular Weight: 37,266 Da
• NCBI Official Full Name: natural cytotoxicity triggering receptor 1
• NCBI Official Synonym Full Names: natural cytotoxicity triggering receptor 1
• NCBI Official Symbol: Ncr1
• NCBI Official Synonym Symbols: Ly94; NKp46
• NCBI Protein Information: natural cytotoxicity triggering receptor 1
• UniProt Protein Name: Natural cytotoxicity triggering receptor 1
• Protein Family: Niemann-Pick type C-related protein
• UniProt Gene Name: Ncr1
• UniProt Synonym Gene Names: Ly94; mAR-1; NK-p46; NKp46; mNKp46

Uniprot Description

NCR1: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Belongs to the natural cytotoxicity receptor (NCR) family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 7|7 A1

Biological Process: defense response to virus; detection of virus