LAMP1/CD107a Active Protein | LAMP1 active protein

Human CellExp LAMP1 / CD107a, human recombinant

Cat. Num. AAA844130

• Gene Names: LAMP1; LAMPA; CD107a; LGP120
• Applications: SDS-Page
• Purity: >=95%
• Synonyms: LAMP1/CD107a; Human CellExp LAMP1 / CD107a; human recombinant; LAMP1; CD107a; LAMP1 active protein

• Host: HEK293 cells
• Purity/Purification: >=95%
• Form/Format: Lyophilized from 0.22 mum filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.; Appearance: Lyophilized
• Sequence Length: 417

• Applicable Applications for LAMP1 active protein: SDS-PAGE
• Solubility/Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 month. For extended storage, it is recommended to store at -20 degree C.
• Endotoxin Level: <1 EU/mug by LAL method
• Biological Activity: Measured by its binding ability in a functional ELISA. When rhLAMP1 /CD107a is coated at 1 ug/ml, rhGalectin?3 binds with an apparent Kd <30 nM.
• Results: Measured by its binding ability in a functional ELISA. When rhLAMP1 /CD107a is coated at 1 ug/ml, rhGalectin?3 binds with an apparent Kd <30 nM.
• Handling: Centrifuge the vial prior to opening.
• Preparation and Storage: At -20 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for LAMP1 active protein

Background: Lysosomal-associated membrane protein 1 (LAMP1) is also known as CD107a (Cluster of Differentiation 107a). LAMP1 / CD107a belongs to the LAMP family. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. CD107a has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells.

Product Categories/Family for LAMP1 active protein

Proteins and Enzymes; Human cell expressed recombinant proteinsCytokines; Growth Factors & Hormones; Human cell expressed recombinant proteinsProteins and Enzymes; Cytokines; Growth Factors & Hormones; CDsProteins and Enzymes; Cytokines; Growth Factors &

NCBI and Uniprot Product Information

• NCBI GI #: 112380628
• NCBI GeneID: 3916
• NCBI Accession #: NP_005552.3
• NCBI GenBank Nucleotide #: NM_005561.3
• UniProt Accession #: P11279; Q8WU33; Q96I40; Q9BRD2; Q9NP13; B4DWL3
• Molecular Weight: This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 39.2 kDa. The predicted N-terminus is Ala 29. DTT-reduced Protein migrates as 60-100 kDa due to different glycosylation.
• NCBI Official Full Name: lysosome-associated membrane glycoprotein 1
• NCBI Official Synonym Full Names: lysosomal-associated membrane protein 1
• NCBI Official Symbol: LAMP1
• NCBI Official Synonym Symbols: LAMPA; CD107a; LGP120
• NCBI Protein Information: lysosome-associated membrane glycoprotein 1
• UniProt Protein Name: Lysosome-associated membrane glycoprotein 1
• Protein Family: Lysosome-associated membrane glycoprotein
• UniProt Gene Name: LAMP1
• UniProt Synonym Gene Names: LAMP-1; Lysosome-associated membrane protein 1
• UniProt Entry Name: LAMP1_HUMAN

NCBI Description

The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]

Uniprot Description

LAMP1: Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. Belongs to the LAMP family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: multivesicular body; membrane; cell soma; integral to plasma membrane; lysosome; cytoplasm; late endosome; dendrite; plasma membrane; melanosome; endosome membrane; sarcolemma; external side of plasma membrane

Molecular Function: protein domain specific binding; protein binding; enzyme binding

Biological Process: positive regulation of natural killer cell degranulation; induction of apoptosis by granzyme; viral reproduction; protein stabilization; autophagic cell death; autophagy; positive regulation of natural killer cell mediated cytotoxicity