IL-34 active protein
Human IL-34
NCBI and Uniprot Product Information
NCBI Description
Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]
Uniprot Description
Function: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Ref.1 Ref.6 Ref.7 Ref.8
Subunit structure: Homodimer. Interacts with CSF1R. Ref.1 Ref.6 Ref.8
Subcellular location: Secreted Ref.1.
Tissue specificity: Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon. Ref.1
Sequence similarities: Belongs to the IL-34 family.
Research Articles on IL-34
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Product Notes
The IL-34 il34 (Catalog #AAA692023) is an Active Protein produced from HEK 293 Cells and is intended for research purposes only. The product is available for immediate purchase. The Human IL-34 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: NEPLEMWPLT QNEECTVTGF LRDKLQYRSR LQYMKHYFPI NYKISV PYEG VFRIANVTRL QRAQVSEREL RYLWVLVSLS ATESVQDVLL E GHPSWKYLQ EVETLLLNVQ QGLTDVEVSP KVESVLSLLN APGPNLK LVR PKALLDNCFR VMELLYCSCC KQSSVLNWQD CEVPSPQSCS PE PSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL LPHHHHHH HH. It is sometimes possible for the material contained within the vial of "IL-34, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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