SDS-PAGE
HDAC8 / HDACL1 recombinant protein
Recombinant Mouse HDAC8 / HDACL1 Protein (His tag)
SDS-PAGE
SDS-PAGE
NCBI and Uniprot Product Information
Uniprot Description
HDAC8: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility. Belongs to the histone deacetylase family. HD type 1 subfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.5.1.98; Hydrolase
Chromosomal Location of Human Ortholog: X|X D
Cellular Component: cytoplasm; histone deacetylase complex; nucleus; plasma membrane
Molecular Function: histone deacetylase activity; Hsp70 protein binding; Hsp90 protein binding; transcription factor binding
Biological Process: establishment and/or maintenance of chromatin architecture; negative regulation of protein ubiquitination; regulation of protein stability; regulation of telomere maintenance; sister chromatid cohesion
Research Articles on HDAC8 / HDACL1
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Product Notes
The HDAC8 / HDACL1 hdac8 (Catalog #AAA2547065) is a Recombinant Protein produced from Baculovirus-Insect Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant mouse HDAC8 consists of 387 amino acids and has a calculated molecular mass of 43.1 kDa. It migrates as an approximately 46 kDa band in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the HDAC8 / HDACL1 hdac8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HDAC8 / HDACL1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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