GuineaPig heparin-binding epidermal growth factor-like growth factor ELISA Kit | HB-EGF elisa kit
Guinea Pig heparin-binding epidermal growth factor-like growth factor ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Function: May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF
By similarity. Plays an important role in the proper development of cranial nerves by inhibting the migration of the cranial neural crest cells (NCCs) migration into the odd-numbered neuromeres (r3 and r5) of the hindbrain. Plays a role in mediating v-Jun-induced oncogenic transformation. Ref.1 Ref.2
Subunit structure: Interacts with CNIH2. Ref.2
Subcellular location: Heparin-binding EGF-like growth factor: Secreted › extracellular space
By similarity. Note: Mature HB-EGF is released into the extracellular space and probably binds to a receptor
By similarity.Proheparin-binding EGF-like growth factor: Cell membrane; Single-pass type I membrane protein
Developmental stage: Expressed uniformly in the embryonic hindbrain. Ref.2
Induction: Strongly induced in embryonic fibroblasts transformed by v-Jun. Ref.1
Sequence similarities: Contains 1 EGF-like domain.
Research Articles on HB-EGF
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Product Notes
The GuineaPig HB-EGF hbegf (Catalog #AAA729276) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA729276 ELISA Kit recognizes GuineaPig HB-EGF. It is sometimes possible for the material contained within the vial of "heparin-binding epidermal growth factor-like growth factor, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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