Hamster Serine Pyruvate Aminotransferase (AGXT) ELISA Kit | AGXT elisa kit
Hamster Serine Pyruvate Aminotransferase (AGXT) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]
Uniprot Description
AGXT: Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1); also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
Protein type: Transferase; Mitochondrial; Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.6.1.44; Motility/polarity/chemotaxis; EC 2.6.1.51
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: mitochondrial matrix; peroxisomal matrix; peroxisome
Molecular Function: alanine-glyoxylate transaminase activity; amino acid binding; protein binding; protein homodimerization activity; protein self-association; pyridoxal phosphate binding; receptor binding; serine-pyruvate transaminase activity; transaminase activity
Biological Process: glycine biosynthetic process, by transamination of glyoxylate; glyoxylate catabolic process; glyoxylate metabolic process; L-alanine catabolic process; L-cysteine catabolic process; Notch signaling pathway; oxalic acid secretion; proteasomal protein catabolic process; pyruvate biosynthetic process; response to cAMP; response to glucocorticoid stimulus
Disease: Hyperoxaluria, Primary, Type I
Research Articles on AGXT
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Product Notes
The Hamster AGXT agxt (Catalog #AAA9350614) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9350614 ELISA Kit recognizes Hamster AGXT. It is sometimes possible for the material contained within the vial of "Serine Pyruvate Aminotransferase (AGXT), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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