Hamster Inositol 1,4,5-Trisphosphate Receptor Type 2 (ITPR2) ELISA Kit | ITPR2 elisa kit
Hamster Inositol 1,4,5-Trisphosphate Receptor Type 2 (ITPR2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
Uniprot Description
IP3R2: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA. Most normal tissues displayed weak to moderate cytoplasmic positivity. Strong staining was observed in the gastrointestinal tract, hepatocytes and exocrine pancreas. Short isoform Is found in skeletal muscle and heart. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylation by PKA increases calcium release. Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor. Belongs to the InsP3 receptor family. 2 isoforms of the human protein are produced by alternative splicing. The short isoform is found in skeletal muscle and heart.
Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Channel, calcium; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p11
Cellular Component: cell cortex; endoplasmic reticulum membrane; integral to membrane; membrane; plasma membrane; receptor complex; sarcoplasmic reticulum membrane
Molecular Function: calcium ion transmembrane transporter activity; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity; phosphoinositide binding
Biological Process: blood coagulation; energy reserve metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; inositol phosphate-mediated signaling; nerve growth factor receptor signaling pathway; phospholipase C activation; platelet activation; regulation of insulin secretion; response to hypoxia; signal transduction; stimulatory C-type lectin receptor signaling pathway; transport; vascular endothelial growth factor receptor signaling pathway
Disease: Anhidrosis, Isolated, With Normal Sweat Glands
Research Articles on ITPR2
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Product Notes
The Hamster ITPR2 itpr2 (Catalog #AAA9349964) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9349964 ELISA Kit recognizes Hamster ITPR2. It is sometimes possible for the material contained within the vial of "Inositol 1,4,5-Trisphosphate Receptor Type 2 (ITPR2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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