Hamster Gamma-Aminobutyric Acid Receptor Subunit Alpha-1 (GABRA1) ELISA Kit | GABRA1 elisa kit
Hamster Gamma-Aminobutyric Acid Receptor Subunit Alpha-1 (GABRA1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
GABRA1: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Defects in GABRA1 are the cause of childhood absence epilepsy type 4 (ECA4). A subtype of idiopathic generalized epilepsy characterized by onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures may develop. Absence seizures may either remit or persist into adulthood. Defects in GABRA1 are the cause of juvenile myoclonic epilepsy type 5 (EJM5). A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
Protein type: Transporter, ion channel; Channel, ligand-gated; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5q34
Cellular Component: cell junction; integral to plasma membrane; plasma membrane; postsynaptic membrane
Molecular Function: chloride channel activity; drug binding; extracellular ligand-gated ion channel activity; GABA receptor activity; GABA-A receptor activity
Biological Process: gamma-aminobutyric acid signaling pathway; synaptic transmission; synaptic transmission, GABAergic; transmembrane transport; transport
Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 13; Epileptic Encephalopathy, Early Infantile, 19
Research Articles on GABRA1
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Product Notes
The Hamster GABRA1 gabra1 (Catalog #AAA9358147) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9358147 ELISA Kit recognizes Hamster GABRA1. It is sometimes possible for the material contained within the vial of "Gamma-Aminobutyric Acid Receptor Subunit Alpha-1 (GABRA1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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