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Western Blot (WB) (Western Blot analysis of LoVo cell using GABRA1 Polyclonal Antibody at dilution of 1:300)

Rabbit GABRA1 Polyclonal Antibody | anti-GABRA1 antibody

GABRA1 Polyclonal Antibody

Gene Names
GABRA1; EJM; ECA4; EJM5; EIEE19
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Antigen affinity purification
Synonyms
GABRA1; Polyclonal Antibody; GABRA1 Polyclonal Antibody; EJM; ECA4; EJM5; anti-GABRA1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen affinity purification
Concentration
1.9mg/mL (varies by lot)
Sequence Length
456
Applicable Applications for anti-GABRA1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
WB: 1:500-1:2000
IHC: 1:25-1:100
Immunogen
Synthetic peptide of human GABRA1
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of LoVo cell using GABRA1 Polyclonal Antibody at dilution of 1:300)

Western Blot (WB) (Western Blot analysis of LoVo cell using GABRA1 Polyclonal Antibody at dilution of 1:300)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer using GABRA1 Polyclonal Antibody at dilution of 1:30)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human thyroid cancer using GABRA1 Polyclonal Antibody at dilution of 1:30)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human gastric cancer using GABRA1 Polyclonal Antibody at dilution of 1:30)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human gastric cancer using GABRA1 Polyclonal Antibody at dilution of 1:30)
Related Product Information for anti-GABRA1 antibody
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene
Product Categories/Family for anti-GABRA1 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
51,802 Da
NCBI Official Full Name
gamma-aminobutyric acid receptor subunit alpha-1
NCBI Official Synonym Full Names
gamma-aminobutyric acid (GABA) A receptor, alpha 1
NCBI Official Symbol
GABRA1
NCBI Official Synonym Symbols
EJM; ECA4; EJM5; EIEE19
NCBI Protein Information
gamma-aminobutyric acid receptor subunit alpha-1; GABA(A) receptor subunit alpha-1; GABA(A) receptor, alpha 1
UniProt Protein Name
Gamma-aminobutyric acid receptor subunit alpha-1
UniProt Gene Name
GABRA1
UniProt Entry Name
GBRA1_HUMAN

NCBI Description

This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

GABRA1: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Defects in GABRA1 are the cause of childhood absence epilepsy type 4 (ECA4). A subtype of idiopathic generalized epilepsy characterized by onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures may develop. Absence seizures may either remit or persist into adulthood. Defects in GABRA1 are the cause of juvenile myoclonic epilepsy type 5 (EJM5). A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.

Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel; Transporter

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function: chloride channel activity; GABA-A receptor activity; GABA receptor activity; drug binding; extracellular ligand-gated ion channel activity

Biological Process: synaptic transmission; transport; synaptic transmission, GABAergic; transmembrane transport; gamma-aminobutyric acid signaling pathway

Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 13; Epileptic Encephalopathy, Early Infantile, 19

Research Articles on GABRA1

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Product Notes

The GABRA1 gabra1 (Catalog #AAA2530282) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GABRA1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GABRA1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:2000 IHC: 1:25-1:100. Researchers should empirically determine the suitability of the GABRA1 gabra1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GABRA1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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