Hamster Complement Component 1, Q Subcomponent B (C1qB) ELISA Kit | C1qB elisa kit
Hamster Complement Component 1, Q Subcomponent B (C1qB) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq, Jul 2008]
Uniprot Description
C1QB: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QB are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1p36.12
Cellular Component: collagen; complement component C1 complex; extracellular region
Molecular Function: protein binding; protein homodimerization activity
Biological Process: complement activation; complement activation, classical pathway; innate immune response; inner ear development
Disease: C1q Deficiency
Research Articles on C1qB
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Product Notes
The Hamster C1qB c1qb (Catalog #AAA9369534) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9369534 ELISA Kit recognizes Hamster C1qB. It is sometimes possible for the material contained within the vial of "Complement Component 1, Q Subcomponent B (C1qB), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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