Cardiotrophin-1 Blocking Peptide | H31 blocking peptide

Cardiotrophin-1 (H31) Peptide

Cat. Num. AAA3004119

• Gene Names: CTF1; CT1; CT-1
• Applications: Blocking
• Purity: Synthetic peptide Cardiotrophin-1 (H31). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: Cardiotrophin-1; Cardiotrophin-1 (H31) Peptide; CT-1; CTF1; Cardiotrophin1; CT1; Cardiotrophin 1; CT 1; H31 blocking peptide

• Specificity: This peptide can be used with studies using MBS3004118 Cardiotrophin-1 (H31) pAb.
• Purity/Purification: Synthetic peptide Cardiotrophin-1 (H31). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 201

• Applicable Applications for H31 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for H31 blocking peptide

Cardiotrophin-1 (CT-1) is a member of the IL-6 family of cytokines, which signal through gp130 receptor complexes. gp130 complexes with several different receptor subunits to transmit signals from Cardiotrophin-1, IL-6, LIF, OSM, CNTF and IL-11. Cardiotrophin-1 binds to and activates the leukemia inhibitory factor (LIF) receptor/gp130 receptor complex and has been shown to induce hypertrophy in cardiac myocytes in vitro. Cardiotrophin-1, a secreted protein expressed at high levels in myocardium during cardiogenesis, has been shown to promote proliferation and survival of embryonic cardiomyocytes, suggesting a role for Cardiotrophin-1 in the activation of gp130 during cardiac development.

NCBI and Uniprot Product Information

• NCBI GI #: 4503121
• NCBI GeneID: 1489
• NCBI Accession #: NP_001321.1
• NCBI GenBank Nucleotide #: NP_001321.1
• UniProt Accession #: Q16619
• NCBI Official Full Name: cardiotrophin-1 isoform 1
• NCBI Official Synonym Full Names: cardiotrophin 1
• NCBI Official Symbol: CTF1
• NCBI Official Synonym Symbols: CT1; CT-1
• NCBI Protein Information: cardiotrophin-1
• UniProt Protein Name: Cardiotrophin-1
• Protein Family: Cardiotrophin
• UniProt Gene Name: CTF1
• UniProt Synonym Gene Names: CT-1
• UniProt Entry Name: CTF1_HUMAN

NCBI Description

The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Uniprot Description

CTF1: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: extracellular space; extracellular region

Molecular Function: leukemia inhibitory factor receptor binding; cytokine activity

Biological Process: nervous system development; cell proliferation; muscle development; cell-cell signaling; leukemia inhibitory factor signaling pathway; positive regulation of cell proliferation; neuron development