Guinea Pig Chordin-like protein 2 (CHRDL2) ELISA Kit | CHRDL2 elisa kit
Guinea pig Chordin-like protein 2 (CHRDL2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015]
Uniprot Description
CHRDL2: May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation. Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q14
Cellular Component: extracellular space; cytoplasm
Biological Process: ossification; cartilage development; cell differentiation; negative regulation of BMP signaling pathway
Research Articles on CHRDL2
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Product Notes
The Guinea Pig CHRDL2 chrdl2 (Catalog #AAA7205754) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7205754 ELISA Kit recognizes Guinea Pig CHRDL2. It is sometimes possible for the material contained within the vial of "Chordin-like protein 2 (CHRDL2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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