Rabbit CHRDL2 Polyclonal Antibody | anti-CHRDL2 antibody

CHRDL2 Polyclonal Antibody

Cat. Num. AAA3015407

• Gene Names: CHRDL2; BNF1; CHL2; FKSG37
• Reactivity: Human, Mouse, Rat, Cow, Sheep
• Applications: Western Blot
• Purity: affinity purified by Protein A
• Synonyms: CHRDL2; Polyclonal Antibody; CHRDL2 Polyclonal Antibody; BNF1; Breast tumor novel factor 1; CHL2; chordin like 2; Chordin like protein 2 precursor; Chordin related protein 2; CRDL2_HUMAN.; anti-CHRDL2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat, Cow, Sheep
• Clonality: Polyclonal
• Specificity: CHRDL2 Polyclonal Antibody detects endogenous levels of CHRDL2 protein.
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 126% Glycerol.

• Applicable Applications for anti-CHRDL2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-2000
• Immunogen: KLH conjugated synthetic peptide derived from human CHRDL2:351-429/429
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -45 degree C long term. Avoid freeze-thaw cycles.

Testing Data

(Primary: Anti- CHRDL2 at 1/1000 dilution)

Related Product Information for anti-CHRDL2 antibody

CHRDL2 is a novel chordin like protein that can act as a BMP antagonist. A member of the chordin family of proteins, it contains a signal peptide and three CR (cysteine-rich repeat) domains. When expressed as a recombinant protein it is secreted and binds to activin A, but not to BMP-2, -4, -6. Differential expression has been detected in developing chondrocytes, myoblasts, osteoblasts, and osteoarthritic joints. Complex alternative splicing of CHRDL2 potentially results in distinct isoforms that differ at their C termini, in the expression of signal peptide, and in the content of CR domains. CHRDL2 was originally characterized as a novel protein exclusively expressed in breast, lung, and colon tumors.

NCBI and Uniprot Product Information

• NCBI GI #: 510937050
• NCBI GeneID: 25884
• NCBI Accession #: NP_001265402.1
• NCBI GenBank Nucleotide #: NM_001278473.1
• UniProt Accession #: Q6WN34; Q6WN30; Q6WN31; Q6WN32; Q7Z5J3; A5PKU9
• Molecular Weight: 47,495 Da
• NCBI Official Full Name: chordin-like protein 2 isoform 2
• NCBI Official Synonym Full Names: chordin-like 2
• NCBI Official Symbol: CHRDL2
• NCBI Official Synonym Symbols: BNF1; CHL2; FKSG37
• NCBI Protein Information: chordin-like protein 2; BNF-1; chordin-related protein 2; breast tumor novel factor 1
• UniProt Protein Name: Chordin-like protein 2
• Protein Family: Chordin-like protein
• UniProt Gene Name: CHRDL2
• UniProt Synonym Gene Names: BNF1; CHL2; UNQ765/PRO1557; BNF-1
• UniProt Entry Name: CRDL2_HUMAN

NCBI Description

This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015]

Uniprot Description

CHRDL2: May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation. Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11q14

Cellular Component: extracellular space; cytoplasm

Biological Process: ossification; cartilage development; cell differentiation; negative regulation of BMP signaling pathway