Guinea Pig Bromodomain-containing protein 4 (BRD4) ELISA Kit | BRD4 elisa kit
Guinea pig Bromodomain-containing protein 4 (BRD4) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
BRD4: an atypical protein kinase of the Brd family. Contains a double bromodomain. Binds to chromatin and regulates cell cycle progression at multiple stages. Associates with chromosomes during mitosis. The cognate gene is the chromosome 19 target of translocation t(15;19)(q13;p13.1), resulting in the BRD4-NUT oncogene identified in a lethal carcinoma of young people. Binds to papillomavirus E2 protein and is required for its transforming ability. Two alternatively spliced isoforms have been described.
Protein type: Protein kinase, atypical; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; ATYPICAL group; BRD family
Chromosomal Location of Human Ortholog: 19p13.1
Cellular Component: nucleoplasm; transcription elongation factor complex b; condensed nuclear chromosome; cytoplasm; nuclear chromatin; chromosome; nucleus
Molecular Function: protein binding; DNA binding; p53 binding; chromatin binding
Biological Process: G1/S-specific transcription in mitotic cell cycle; chromatin remodeling; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; viral reproduction; positive regulation of RNA elongation from RNA polymerase II promoter; regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; inner cell mass cell proliferation; response to DNA damage stimulus; positive regulation of DNA binding; chromosome segregation
Research Articles on BRD4
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Product Notes
The Guinea Pig BRD4 brd4 (Catalog #AAA7231631) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7231631 ELISA Kit recognizes Guinea Pig BRD4. It is sometimes possible for the material contained within the vial of "Bromodomain-containing protein 4 (BRD4), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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