Rat guanylate cyclase 2E ELISA Kit | GUCY2E elisa kit
Rat Guanylyl cyclase GC-E, GUCY2E ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
an orphan membrane guanylyl cyclase [RGD, Feb 2006]
Uniprot Description
GUCY2D: Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. Defects in GUCY2D are the cause of Leber congenital amaurosis type 1 (LCA1). LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children. Defects in GUCY2D are the cause of cone-rod dystrophy type 6 (CORD6). CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Protein type: Lyase; Protein kinase, RGC; Guanylyl cyclase; EC 4.6.1.2; Kinase, protein; Protein kinase, dual-specificity (receptor); Nucleotide Metabolism - purine; Membrane protein, integral; Receptor, misc.; RGC group; RGC family
Cellular Component: plasma membrane; integral to membrane
Molecular Function: identical protein binding; protein binding; guanylate cyclase activity; GTP binding; ATP binding; protein kinase activity
Biological Process: cGMP biosynthetic process; visual perception; protein amino acid phosphorylation
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Product Notes
The Rat GUCY2E gucy2e (Catalog #AAA9332272) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332272 ELISA Kit recognizes Rat GUCY2E. It is sometimes possible for the material contained within the vial of "guanylate cyclase 2E, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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