Human guanylate cyclase 1, soluble, beta 3 ELISA Kit | GUCY1B3 elisa kit

Human Guanylate cyclase soluble subunit beta-1, GUCY1B3 ELISA Kit

Cat. Num. AAA9335658

• Gene Names: GUCY1B3; GUCB3; GC-SB3; GUC1B3; GUCSB3; GUCY1B1; GC-S-beta-1
• Reactivity: Human
• Synonyms: guanylate cyclase 1; soluble; beta 3; Human Guanylate cyclase soluble subunit beta-1; GUCY1B3 ELISA Kit; Human Guanylate cyclase soluble subunit beta-1 (GUCY1B3) ELISA kit; GC-S-beta-1; GC-SB3; GUC1B3; GUCB3; GUCSB3; GUCY1B1; ; GUCY1B3 elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Body fluids, tissue homogenates, secretions or feces samples
• Assay Type: Quantitative Sandwich
• Detection Range: 0.25 ng/ml - 8 ng/ml
• Sensitivity: 0.1 ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for GUCY1B3 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of GUCY1B3 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 4504215
• NCBI GeneID: 2983
• NCBI Accession #: NP_000848.1
• NCBI GenBank Nucleotide #: NM_000857.3
• UniProt Accession #: Q02153; Q86WY5; B7Z426
• Molecular Weight: 70,514 Da
• NCBI Official Full Name: guanylate cyclase soluble subunit beta-1 isoform 2
• NCBI Official Synonym Full Names: guanylate cyclase 1, soluble, beta 3
• NCBI Official Symbol: GUCY1B3
• NCBI Official Synonym Symbols: GUCB3; GC-SB3; GUC1B3; GUCSB3; GUCY1B1; GC-S-beta-1
• NCBI Protein Information: guanylate cyclase soluble subunit beta-1; GCS-beta-1; GCS-beta-3; soluble guanylate cyclase small subunit; guanylate cyclase soluble subunit beta-3
• UniProt Protein Name: Guanylate cyclase soluble subunit beta-1
• Protein Family: Guanylate cyclase soluble
• UniProt Gene Name: GUCY1B3
• UniProt Synonym Gene Names: GUC1B3; GUCSB3; GUCY1B1; GCS-beta-1; GCS-beta-3
• UniProt Entry Name: GCYB1_HUMAN

NCBI Description

This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Uniprot Description

GUCY1B3: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Heterodimer of an alpha and a beta chain. 2 isoforms of the human protein are produced by alternative splicing

Protein type: Guanylyl cyclase; Nucleotide Metabolism - purine; Receptor, misc.; Lyase; EC 4.6.1.2

Chromosomal Location of Human Ortholog: 4q31.3-q33

Cellular Component: guanylate cyclase complex, soluble; intracellular membrane-bound organelle; cytoplasm

Molecular Function: guanylate cyclase activity; GTP binding; protein heterodimerization activity; metal ion binding; heme binding; receptor activity; Hsp90 protein binding

Biological Process: cGMP biosynthetic process; blood circulation; blood coagulation; nitric oxide mediated signal transduction