Glutathione Peroxidase 3 Recombinant Protein | GPX3 recombinant protein

Glutathione Peroxidase 3, Recombinant, Human (GPX3, GSHPx-3, GPx-3, GSHPx-P, GPx-P, GPXP)

Cat. Num. AAA637817

• Gene Names: GPX3; GPx-P; GSHPx-3; GSHPx-P
• Purity: Highly Purified; >90% (SDS-PAGE)
• Synonyms: Glutathione Peroxidase 3; Recombinant; Human (GPX3; GSHPx-3; GPx-3; GSHPx-P; GPx-P; GPXP); GPX3 recombinant protein

• Host: Human, HEK 293 cells
• Purity/Purification: Highly Purified; >90% (SDS-PAGE)
• Form/Format: Supplied as a 0.2um-filtered solution in PBS, pH7.2.
• Sequence: Human GPX3 (aa 21-226) is fused at the N-terminus to a DYKDDDDK-tag.

• Preparation and Storage: Short-term Storage: +4 degree C; Long-term Storage: -20 degree C; Working aliquots are stable for up to 3 months when stored at -20 degree C.

Related Product Information for GPX3 recombinant protein

Glutathione peroxidase 3 (GPX3) is a selenium-dependent extracellular enzyme, protecting cells and enzymes from oxidative damage by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxides. GPX3 is involved in inflammatory bowel disease, in asthma and in diabetes. The activity of GPX3 is significantly reduced in the plasma and tissue of cancer patients. Recently, GPX3 was suggested to serve as a molecular marker for the identification of clear cell type ovarian adenocarcinoma.

Product Categories/Family for GPX3 recombinant protein

Molecular Biology; MB-Enzymes; Peroxidase

NCBI and Uniprot Product Information

• NCBI GI #: 6006001
• NCBI GeneID: 2878
• NCBI Accession #: NP_002075.2
• NCBI GenBank Nucleotide #: NM_002084.3
• UniProt Accession #: P22352; O43787; Q86W78; Q9NZ74; Q9UEL1
• Molecular Weight: ~30kD (SDS-PAGE)
• NCBI Official Full Name: glutathione peroxidase 3
• NCBI Official Synonym Full Names: glutathione peroxidase 3 (plasma)
• NCBI Official Symbol: GPX3
• NCBI Official Synonym Symbols: GPx-P; GSHPx-3; GSHPx-P
• NCBI Protein Information: glutathione peroxidase 3; GPx-3; plasma glutathione peroxidase; extracellular glutathione peroxidase
• UniProt Protein Name: Glutathione peroxidase 3
• Protein Family: Glutathione peroxidase
• UniProt Gene Name: GPX3
• UniProt Synonym Gene Names: GPXP; GPx-3; GSHPx-3; GPx-P; GSHPx-P
• UniProt Entry Name: GPX3_HUMAN

NCBI Description

This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]

Uniprot Description

GPX3: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. Belongs to the glutathione peroxidase family.

Protein type: Oxidoreductase; Secreted, signal peptide; EC 1.11.1.9; Secreted; Lipid Metabolism - arachidonic acid; Other Amino Acids Metabolism - glutathione

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: extracellular space; extracellular region

Molecular Function: selenium binding; glutathione peroxidase activity; transcription factor binding

Biological Process: response to reactive oxygen species; response to lipid hydroperoxide; hydrogen peroxide catabolic process; protein homotetramerization