Human G protein-coupled receptor 98 ELISA Kit | GPR98 elisa kit

Human G-protein coupled receptor 98, GPR98 ELISA Kit

Cat. Num. AAA9325792

• Gene Names: GPR98; FEB4; MASS1; USH2B; USH2C; VLGR1; VLGR1b
• Reactivity: Human
• Synonyms: G protein-coupled receptor 98; Human G-protein coupled receptor 98; GPR98 ELISA Kit; Human G-protein coupled receptor 98 (GPR98) ELISA kit; DKFZp761P0710; FEB4; KIAA0686; MASS1; USH2B; USH2C; VLGR1; VLGR1b; monogenic; audiogenic seizure susceptibility 1 homolog; very large G protein-coupled receptor 1; GPR98 elisa kit

• Reactivity: Human

• Samples: Mouse Body Fluids And Tissue Homogenates
• Assay Type: Quantitative Sandwich
• Detection Range: 0.625ng/ml-20ng/ml
• Sensitivity: 0.1ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for GPR98 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only! This kit is intended to be used for determine the level of GPR84 (hereafter termed "analyte") in undiluted original Mouse body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 113722120
• NCBI GeneID: 84059
• NCBI Accession #: NP_115495.3
• NCBI GenBank Nucleotide #: NM_032119.3
• UniProt Accession #: Q8WXG9; O75171; Q8TF58; Q9H0X5; Q9UL61
• Molecular Weight: 693,069 Da
• NCBI Official Full Name: G-protein coupled receptor 98
• NCBI Official Synonym Full Names: G protein-coupled receptor 98
• NCBI Official Symbol: GPR98
• NCBI Official Synonym Symbols: FEB4; MASS1; USH2B; USH2C; VLGR1; VLGR1b
• NCBI Protein Information: G-protein coupled receptor 98; usher syndrome type-2C protein; very large G protein-coupled receptor 1; very large G-protein coupled receptor 1; monogenic, audiogenic seizure susceptibility 1 homolog; monogenic audiogenic seizure susceptibility protein 1 homolog
• UniProt Protein Name: G-protein coupled receptor 98
• Protein Family: G-protein coupled receptor
• UniProt Gene Name: GPR98
• UniProt Synonym Gene Names: KIAA0686; KIAA1943; MASS1; VLGR1
• UniProt Entry Name: GPR98_HUMAN

NCBI Description

This gene encodes a member of the G-protein coupled receptor superfamily. The encoded protein contains a 7-transmembrane receptor domain, binds calcium and is expressed in the central nervous system. Mutations in this gene are associated with Usher syndrome 2 and familial febrile seizures. Several alternatively spliced transcripts have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

GPR98: Receptor that may have an important role in the development of the central nervous system. Defects in GPR98 are the cause of Usher syndrome type 2C (USH2C). USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses. Defects in GPR98 may be a cause of familial febrile convulsions type 4 (FEB4); also known as familial febrile seizures 4. Febrile convulsions are seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; GPCR, family 2; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q13

Cellular Component: cell surface; membrane; perinuclear region of cytoplasm; cytoplasm; integral to membrane; receptor complex

Molecular Function: G-protein coupled receptor activity; protein binding; myosin binding; calcium ion binding

Biological Process: G-protein coupled receptor protein signaling pathway; nervous system development; cell-cell adhesion; inner ear receptor stereocilium organization and biogenesis; sensory perception of sound; visual perception; sensory perception of light stimulus; photoreceptor cell maintenance; detection of mechanical stimulus involved in sensory perception of sound; maintenance of organ identity; neurological system process

Disease: Febrile Seizures, Familial, 4; Usher Syndrome, Type Iic