GPR37 recombinant protein

Recombinant Human GPR37 Protein (His tag)

Cat. Num. AAA2545303

• Gene Names: GPR37; PAELR; EDNRBL; hET(B)R-LP
• Purity: > 80 % as determined by SDS-PAGE
• Synonyms: GPR37; Recombinant Human GPR37 Protein (His tag); EDNRBL; PAELR; hET (B)R-LP; GPR37 recombinant protein

• Host: Human Cells
• Purity/Purification: > 80 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 613

• Application Notes: The secreted recombinant human GPR37 comprises 250 amino acids and has a predicted molecular mass of 26.6 kDa. ? The apparent molecular mass of rh GPR37 is approximately 30-45 kDa in SDS-PAGE under reducing conditions due to different glycosylation.
• Predicted N Terminal: Ala 27
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for GPR37 recombinant protein

Background: GPR37 (cathepsin Z) is an orphan receptor which belongs to the G-protein coupled receptor 1 family. G protein coupled receptors is a large protein family comprised by transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. They only exists in eukaryotes, including yeast, choanoflagellates, and animals. These receptors are binded and activated by light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters. These ligands vary in size from small molecules to peptides to large proteins. G protein-coupled receptors are involved in many diseases, and are also the target of approximately 40% of all modern medicinal drugs. GPR37 is expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. GPR37 may have a unique functional role in the central nervous system.

Description: A DNA sequence encoding the human GPR37 (NP_005293.1) the first extracellular domaqin (Met 1-Met 265) was fused with a polyhistidine tag at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 4885323
• NCBI GeneID: 2861
• NCBI Accession #: NP_005293.1
• NCBI GenBank Nucleotide #: NM_005302.3
• UniProt Accession #: O15354; O00348; O14768; Q8TD39; A4D0Y6
• Molecular Weight: 67,114 Da
• NCBI Official Full Name: prosaposin receptor GPR37
• NCBI Official Synonym Full Names: G protein-coupled receptor 37
• NCBI Official Symbol: GPR37
• NCBI Official Synonym Symbols: PAELR; EDNRBL; hET(B)R-LP
• NCBI Protein Information: prosaposin receptor GPR37
• UniProt Protein Name: Prosaposin receptor GPR37
• Protein Family: Prosaposin receptor
• UniProt Gene Name: GPR37
• UniProt Synonym Gene Names: ETBR-LP-1; PAELR

NCBI Description

This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]

Uniprot Description

GPR37: Orphan receptor. May have a unique functional role in the central nervous system. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 7q31.33

Cellular Component: endoplasmic reticulum; integral to plasma membrane; plasma membrane; receptor complex; ubiquitin ligase complex

Molecular Function: G-protein coupled receptor activity; heat shock protein binding; Hsp70 protein binding; peptide binding; peptide receptor activity, G-protein coupled; protein binding; ubiquitin protein ligase binding

Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; positive regulation of MAPKKK cascade