Sheep G Protein Coupled Receptor 183 ELISA Kit | GPR183 elisa kit

Sheep G Protein Coupled Receptor 183 ELISA Kit

Cat. Num. AAA7266129

• Gene Names: GPR183; EBI2; hEBI2
• Reactivity: Sheep
• Synonyms: G Protein Coupled Receptor 183; Sheep G Protein Coupled Receptor 183 ELISA Kit; GPR183 elisa kit

• Reactivity: Sheep
• Sequence Length: 361

• Reproducibility: Intra-Assay: CV<10%; Inter-Assay: CV<15%
• Reactivity Note: No significant cross-reactivity or interference between this antigen and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection, therefore, cross reaction may still exist in some cases.
• Preparation and Storage: Store at 2-8 degree C.; The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition.

Related Product Information for GPR183 elisa kit

This ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of the targets.

Product Categories/Family for GPR183 elisa kit

Signal Transduction; Microbiology; Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 4826706
• NCBI GeneID: 1880
• NCBI Accession #: NP_004942.1
• NCBI GenBank Nucleotide #: NM_004951.5
• UniProt Accession #: P32249; Q53F99; Q5JUH7; B2R8N5
• Molecular Weight: 41,224 Da
• NCBI Official Full Name: G-protein coupled receptor 183
• NCBI Official Synonym Full Names: G protein-coupled receptor 183
• NCBI Official Symbol: GPR183
• NCBI Official Synonym Symbols: EBI2; hEBI2
• NCBI Protein Information: G-protein coupled receptor 183
• UniProt Protein Name: G-protein coupled receptor 183
• Protein Family: G-protein coupled receptor
• UniProt Gene Name: GPR183
• UniProt Synonym Gene Names: EBI21 PublicationManual assertion based on opinion iniRef.1; EBV-induced G-protein coupled receptor 21 PublicationManual assertion based on opinion iniRef.1; hEBI21 PublicationManual assertion based on opinion iniRef.12

NCBI Description

This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008]

Uniprot Description

G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796212, PubMed:22875855, PubMed:22930711). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:22913878). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4+ dendritic cells in bridging channels (). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897). Promotes osteoclast precursor migration to bone surfaces (). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (PubMed:21673108, PubMed:25297897). Signals constitutively also via MAPK1/3 (ERK1/2) ().