G-protein coupled receptor 183 (GPR183) Recombinant Protein | GPR183 recombinant protein

Recombinant Human G-protein coupled receptor 183 (GPR183)

• Gene Names: GPR183; EBI2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: G-protein coupled receptor 183 (GPR183); Recombinant Human G-protein coupled receptor 183 (GPR183); Recombinant G-protein coupled receptor 183 (GPR183); G-protein coupled receptor 183; Epstein-Barr virus-induced G-protein coupled receptor 2; EBI2; EBV-induced G-protein coupled receptor 2; GPR183 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-361
• Sequence: MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
• Sequence Length: 361

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 4826706
• NCBI GeneID: 1880
• NCBI Accession #: NP_004942.1
• NCBI GenBank Nucleotide #: NM_004951.4
• UniProt Accession #: P32249; Q53F99; Q5JUH7; B2R8N5
• Molecular Weight: 41,224 Da
• NCBI Official Full Name: G-protein coupled receptor 183
• NCBI Official Synonym Full Names: G protein-coupled receptor 183
• NCBI Official Symbol: GPR183
• NCBI Official Synonym Symbols: EBI2
• NCBI Protein Information: G-protein coupled receptor 183; EBV-induced G-protein coupled receptor 2; epstein-Barr virus-induced G-protein coupled receptor 2; Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)
• UniProt Protein Name: G-protein coupled receptor 183
• Protein Family: G-protein coupled receptor
• UniProt Gene Name: GPR183
• UniProt Synonym Gene Names: EBI2; EBI2
• UniProt Entry Name: GP183_HUMAN

NCBI Description

This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008]

Uniprot Description

GPR183: Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Binding of 7- alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses. Signals constitutively through G(i)-alpha, but not throughG(s)-alpha or G(q)-alpha. Signals constitutively also via MAPK1/3 (ERK1/2). Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 13q32.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; oxysterol binding

Biological Process: mature B cell differentiation during immune response; G-protein coupled receptor protein signaling pathway; positive regulation of B cell proliferation; immune response; humoral immune response