Glucose-6-phosphate isomerase (Gpi) Recombinant Protein | Gpi recombinant protein

Recombinant Rat Glucose-6-phosphate isomerase (Gpi)

Cat. Num. AAA1425909

• Gene Names: Gpi; Amf; Nlk; Pgi; Phi; Gpi1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Glucose-6-phosphate isomerase (Gpi); Recombinant Rat Glucose-6-phosphate isomerase (Gpi); Gpi recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-558aa; Full Length of Mature Protein
• Sequence: AALTRNPEFQKLLEWHRANSANLKLRELFEADPERFNHFSLNLNTNHGHILLDYSKNLVNKEVLHMLVDLAKSRGVEAARDNMFSGLKINSTEDRAVLHVALRNRSNRSIMMDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKAITDIINIGIGGSDLGPLMVTEALKPYSKGGPRVWFVSNIDGTHIAKTLANLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALSTNTDKVKEFGIDPKNMFEFWDWVGGRYSLWSAIGLSIALHVGFDHFEQLLSGAHWMDQHFMKTPLDKNAPVLLALLGIWYINFYGCETHAMLPYDQYMHRFAAYFQQGDMESNGKYITKSGARVDYQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRNGLHHKILLANFLAQTEALMKGKSPEEARKELQAAGKSPEELEKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQGIIWDINSFDQWGVELGKQLAKKIEPELDGSSAVTSHDSSTNGLIGFIKLQRDTKID

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Gpi recombinant protein

This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. This protein is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.

NCBI and Uniprot Product Information

• NCBI GI #: 46485440
• NCBI GeneID: 292804
• NCBI Accession #: NP_997475.1
• NCBI GenBank Nucleotide #: NM_207592.1
• UniProt Accession #: Q6P6V0
• Molecular Weight: 62,827 Da
• NCBI Official Full Name: glucose-6-phosphate isomerase
• NCBI Official Synonym Full Names: glucose-6-phosphate isomerase
• NCBI Official Symbol: Gpi
• NCBI Official Synonym Symbols: Amf; Nlk; Pgi; Phi; Gpi1
• NCBI Protein Information: glucose-6-phosphate isomerase
• UniProt Protein Name: Glucose-6-phosphate isomerase
• Protein Family: Glucose-6-phosphate isomerase
• UniProt Gene Name: Gpi
• UniProt Synonym Gene Names: PHI

NCBI Description

This gene encodes a member of the glucose phosphate isomerase protein family. A similar protein in human and mouse has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. [provided by RefSeq, Jan 2014]

Uniprot Description

Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons ().