Testing Data
(Gel: 10%SDS-PAGE Lysate: 40ug NIH/3T3 cell Primary antibody: 1/250 dilution Secondary antibody dilution: 1/8000 Exposure time: 2 seconds)
Rabbit VANGL2 Polyclonal Antibody | anti-VANGL2 antibody
VANGL2 Antibody
Immunohistochemistry: 1:15-1:50
Testing Data
(Gel: 10%SDS-PAGE Lysate: 40ug NIH/3T3 cell Primary antibody: 1/250 dilution Secondary antibody dilution: 1/8000 Exposure time: 2 seconds)
Testing Data
(Gel: 10%SDS-PAGE Lysate: 40ug NIH/3T3 cell Primary antibody: 1/250 dilution Secondary antibody dilution: 1/8000 Exposure time: 2 seconds)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/15.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/15.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]
Uniprot Description
VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family.
Protein type: Membrane protein, integral; Adaptor/scaffold; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1q22-q23
Cellular Component: basolateral plasma membrane; apical plasma membrane; plasma membrane; stress fiber; integral to membrane; intercellular junction; ER to Golgi transport vesicle; lateral plasma membrane
Biological Process: positive regulation of JNK activity; convergent extension involved in axis elongation; wound healing; somatic stem cell maintenance; convergent extension involved in neural plate elongation; regulation of Wnt receptor signaling pathway; digestive tract morphogenesis; glomerulus development; Rho protein signal transduction; establishment and/or maintenance of epithelial cell polarity; anterior/posterior pattern formation; apical protein localization; inner ear receptor stereocilium organization and biogenesis; hair follicle development; sensory cilium biogenesis; regulation of actin cytoskeleton organization and biogenesis; neural tube closure; establishment of body hair orientation; somatic stem cell division; establishment of planar polarity; heart looping
Disease: Neural Tube Defects
Research Articles on VANGL2
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Product Notes
The VANGL2 vangl2 (Catalog #AAA9410351) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The VANGL2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's VANGL2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting: 1:200-1:1000 Immunohistochemistry: 1:15-1:50. Researchers should empirically determine the suitability of the VANGL2 vangl2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VANGL2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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