Vasculin Recombinant Protein | GPBP1 recombinant protein

Recombinant Human Vasculin

Cat. Num. AAA1317456

• Gene Names: GPBP1; GPBP; SSH6; VASCULIN
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Vasculin; Recombinant Human Vasculin; GC-rich promoter-binding protein 1; Vascular wall-linked protein; GPBP1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 293-473aa; Partial
• Sequence: MRTDKKSEFLKALKRDRVEEEHEDESRAGSEKDDDSFNLHNSNSTHQERDINRNFDENEIPQENGNASVISQQIIRSSTFPQTDVLSSSLEAEHRLLKEMGWQEDSENDETCAPLTEDEMREFQVISEQLQKNGLRKNGILKNGLICDFKFGPWKNSTFKPTTENDDTETSSSDTSDDDDV
• Sequence Length: 465

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for GPBP1 recombinant protein

Functions as a GC-rich promoter-specific transactivating transcription factor.

Product Categories/Family for GPBP1 recombinant protein

Transcription

References

Vasculin, a novel vascular protein differentially expressed in human atherogenesis.Bijnens A.P.J.J., Gils A., Jutten B., Faber B.C.G., Heeneman S., Kitslaar P.J.E.H.M., Tordoir J.H.M., de Vries C.J.M., Kroon A.A., Daemen M.J.A.P., Cleutjens K.B.J.M.Blood 102:2803-2810(2003) Towards a catalog of human genes and proteins sequencing and analysis of 500 novel complete protein coding human cDNAs.Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.Genome Res. 11:422-435(2001) The full-ORF clone resource of the German cDNA consortium.Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.BMC Genomics 8:399-399(2007) The DNA sequence and comparative analysis of human chromosome 5.Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.Nature 431:268-274(2004)

NCBI and Uniprot Product Information

• NCBI GI #: 291327500
• NCBI GeneID: 65056
• NCBI Accession #: NP_001120707.2
• NCBI GenBank Nucleotide #: NM_001127235.2
• UniProt Accession #: Q86WP2; Q6NSH6; Q9H0D4; Q9H785; Q9NSN4; A6NKW3
• Molecular Weight: 36.8 kDa
• NCBI Official Full Name: vasculin isoform 3
• NCBI Official Synonym Full Names: GC-rich promoter binding protein 1
• NCBI Official Symbol: GPBP1
• NCBI Official Synonym Symbols: GPBP; SSH6; VASCULIN
• NCBI Protein Information: vasculin
• UniProt Protein Name: Vasculin
• Protein Family: Vasculin
• UniProt Gene Name: GPBP1
• UniProt Synonym Gene Names: GPBP; SSH6
• UniProt Entry Name: GPBP1_HUMAN

NCBI Description

This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Uniprot Description

GPBP1: a novel vascular protein differentially expressed in human atherogenesis. Can be found in the plasma, thus it may be a possible marker for atherosclerosis.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: cytoplasm; intracellular membrane-bound organelle; nucleoplasm; nucleus

Molecular Function: DNA binding; protein binding; transcription factor activity

Biological Process: positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; transcription, DNA-dependent