Guanine nucleotide-binding protein alpha-1 subunit (GPA1) Recombinant Protein | GPA1 recombinant protein

Recombinant Arabidopsis thaliana Guanine nucleotide-binding protein alpha-1 subunit (GPA1)

Cat. Num. AAA1105150

• Gene Names: GP ALPHA 1; ARABIDOPSIS THALIANA G PROTEIN ALPHA SUBUNIT 1; ATGPA1; G PROTEIN ALPHA SUBUNIT; G protein alpha subunit 1; G PROTEIN ALPHA SUBUNIT 1; GPA1; T1D16.6; T1D16_6
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Guanine nucleotide-binding protein alpha-1 subunit (GPA1); Recombinant Arabidopsis thaliana Guanine nucleotide-binding protein alpha-1 subunit (GPA1); GPA1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-383, Full length protein
• Sequence: GLLCSRSRHHTEDTDENTQAAEIERRIEQEAKAEKHIRKLLLLGAGESGKSTIFKQIKLLFQTGFDEGELKSYVPVIHANVYQTIKLLHDGTKEFAQNETDSAKYMLSSESIAIGEKLSEIGGRLDYPRLTKDIAEGIETLWKDPAIQETCARGNELQVPDCTKYLMENLKRLSDINYIPTKEDVLYARVRTTGVVEIQFSPVGENKKSGEVYRLFDVGGQRNERRKWIHLFEGVTAVIFCAAISEYDQTLFEDEQKNRMMETKELFDWVLKQPCFEKTSFMLFLNKFDIFEKKVLDVPLNVCEWFRDYQPVSSGKQEIEHAYEFVKKKFEELYYQNTAPDRVDRVFKIYRTTALDQKLVKKTFKLVDETLRRRNLLEAGLL
• Sequence Length: 382

• Species: Arabidopsis thaliana (Mouse-ear cress)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 1063704930
• NCBI GeneID: 817170
• NCBI Accession #: NP_001325056.1
• NCBI GenBank Nucleotide #: NM_001336055.1
• UniProt Accession #: P18064
• Molecular Weight: 44,546 Da
• NCBI Official Full Name: G protein alpha subunit 1
• NCBI Official Symbol: GP ALPHA 1
• NCBI Official Synonym Symbols: ARABIDOPSIS THALIANA G PROTEIN ALPHA SUBUNIT 1; ATGPA1; G PROTEIN ALPHA SUBUNIT; G protein alpha subunit 1; G PROTEIN ALPHA SUBUNIT 1; GPA1; T1D16.6; T1D16_6
• NCBI Protein Information: G protein alpha subunit 1
• UniProt Protein Name: Guanine nucleotide-binding protein alpha-1 subunit
• UniProt Gene Name: GPA1
• UniProt Synonym Gene Names: GP-alpha-1

NCBI Description

Encodes an alpha subunit of a heterotrimeric GTP-binding protein. The active GTP-bound form of GPA1 binds to the GTG1 and GTG2 abscisic acid (ABA) receptors and appears to affect their GTPase and GTP-binding activity, and hence, ABA binding abilities. GPA1 is a positive regulator in ABA-mediated inhibition of stomatal opening. Plants with recessive mutant alleles have complex phenotypes including: reduced brassinolide response, reduced cell divisions, round leaves, short hypocotyls. It is likely to be involved in the signaling events that trigger unfolded protein response-associated cell death. GPA1 is also involved in sugar signaling.

Uniprot Description

Exhibits a fast rate of basal nucleotide exchange. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Together with GCR1, may regulate the cell cycle via a signaling cascade that uses phosphatidylinositol-specific phospholipase C (PI-PLC) as an effector and inositol 1,4,5-trisphosphate (IP3) as a second messenger. Promotes abscisic acid (ABA) responses in guard cells. But, together with GCR1 and GB1, acts as a negative regulator of ABA during seed germination and early seedling development. Involved in the blue light (BL) signaling. Together with GCR1 and ADT3, required for BL-mediated synthesis of phenylpyruvate and subsequently of phenylalanine (Phe), in etiolated seedlings. Modulates root architecture (e.g. lateral root formation). Negatively regulated by RGS1.