Rabbit Glucoprotein 130 ELISA Kit | GP130 elisa kit

Rabbit Glucoprotein 130 ELISA Kit

• Gene Names: IL6ST; CD130; GP130; CDW130; IL-6RB
• Reactivity: Rabbit
• Synonyms: Glucoprotein 130; Rabbit Glucoprotein 130 ELISA Kit; GP130 elisa kit

• Reactivity: Rabbit

• Assay Type: Sandwich
• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 1246098
• NCBI GeneID: 3572
• UniProt Accession #: P40189; Q5FC04; Q9UQ41; A0N0L4
• Molecular Weight: 103,537 Da
• NCBI Official Full Name: gp130
• NCBI Official Synonym Full Names: interleukin 6 signal transducer (gp130, oncostatin M receptor)
• NCBI Official Symbol: IL6ST
• NCBI Official Synonym Symbols: CD130; GP130; CDW130; IL-6RB
• NCBI Protein Information: interleukin-6 receptor subunit beta; CD130 antigen; IL-6R subunit beta; membrane glycoprotein 130; IL-6 receptor subunit beta; membrane glycoprotein gp130; interleukin receptor beta chain; oncostatin-M receptor subunit alpha; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form
• UniProt Protein Name: Interleukin-6 receptor subunit beta
• UniProt Gene Name: IL6ST
• UniProt Synonym Gene Names: IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; gp130
• UniProt Entry Name: IL6RB_HUMAN

NCBI Description

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2010]

Uniprot Description

gp130: gp130 is a ubiquitously expressed type I cytokine family receptor. The receptor systems for IL6, LIF, OSM, CNTF, IL11 AND CT1 utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not directly bind IL6. May have a role in embryonic development. Contains 5 fibronectin type III domains and 1 immunoglobulin-like C2-type domain. Two alternatively spliced isoforms have been described.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: extracellular space; cell soma; membrane; oncostatin-M receptor complex; dendrite; extracellular region; plasma membrane; interleukin-6 receptor complex; external side of plasma membrane

Molecular Function: interleukin-11 binding; protein binding; protein homodimerization activity; interleukin-27 receptor activity; interleukin-6 receptor binding; interleukin-6 binding; leukemia inhibitory factor receptor activity; oncostatin-M receptor activity; growth factor binding; ciliary neurotrophic factor receptor activity; interleukin-6 receptor activity; ciliary neurotrophic factor receptor binding; interleukin-11 receptor activity

Biological Process: glycogen metabolic process; viral reproduction; leukemia inhibitory factor signaling pathway; cytokine and chemokine mediated signaling pathway; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of osteoblast differentiation; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of Notch signaling pathway; positive regulation of acute inflammatory response; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of T cell proliferation; positive regulation of adaptive immune response; positive regulation of astrocyte differentiation; negative regulation of apoptosis