Goat anti-Human FOXN1 Antibody | anti-FOXN1 antibody

FOXN1

Cat. Num. AAA555919

• Gene Names: FOXN1; WHN; RONU; FKHL20
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Affinity Purified
• Synonyms: FOXN1; anti-FOXN1 antibody

• Host: Goat
• Reactivity: Human
• Isotype: IgG
• Purity/Purification: Affinity Purified
• Form/Format: Liquid
• Sequence Length: 648

• Applicable Applications for anti-FOXN1 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Immunogen: Peptide with sequence C-SVYLSPSSKPVALA, from the C Terminus of the FOXN1 protein according to NP_003584.2.

Immunohistochemistry (IHC)

(FOX1N (Dilution:20mug/ml) staining of paraffin embedded Human Thymus Medulla. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Protocol on Data-sheet.)

Related Product Information for anti-FOXN1 antibody

FOX1N or Forkhead box N1 is involved in T-cell development. Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system.

Defects in FOXN1 are the cause of T-cell immunodeficiency congenital alopecia and nail dystrophy. A disorder characterized by the association of congenital alopecia, severe T-cell immunodeficiency, and ridging and pitting of all nails.

NCBI and Uniprot Product Information

• NCBI GI #: 18201913
• NCBI GeneID: 8456
• NCBI Accession #: NP_003584.2
• NCBI GenBank Nucleotide #: NM_003593.2
• UniProt Accession #: O15353
• NCBI Official Full Name: forkhead box protein N1
• NCBI Official Synonym Full Names: forkhead box N1
• NCBI Official Symbol: FOXN1
• NCBI Official Synonym Symbols: WHN; RONU; FKHL20
• NCBI Protein Information: forkhead box protein N1
• UniProt Protein Name: Forkhead box protein N1
• Protein Family: Forkhead box protein
• UniProt Gene Name: FOXN1
• UniProt Synonym Gene Names: RONU; WHN
• UniProt Entry Name: FOXN1_HUMAN

NCBI Description

Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008]

Uniprot Description

FOXN1: Transcriptional regulator involved in development. Defects in FOXN1 are the cause of T-cell immunodeficiency congenital alopecia and nail dystrophy (TIDAND). A disorder characterized by the association of congenital alopecia, severe T-cell immunodeficiency, and ridging and pitting of all nails.

Protein type: Transcription factor; DNA-binding; Cell development/differentiation

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: nucleus

Molecular Function: sequence-specific DNA binding

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; keratinocyte differentiation; organ morphogenesis; epidermis development; epithelial cell proliferation; hair follicle development; thymus development; regulation of T cell differentiation in the thymus; defense response; lymphocyte homeostasis

Disease: T-cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy