Goat Antigen peptide transporter 1 (TAP1) ELISA Kit | TAP1 elisa kit

Goat Antigen peptide transporter 1 (TAP1) ELISA Kit

Cat. Num. AAA7247925

• Gene Names: TAP1; APT1; PSF1; ABC17; ABCB2; PSF-1; RING4; TAP1N; D6S114E; TAP1*0102N
• Reactivity: Goat
• Synonyms: Antigen peptide transporter 1 (TAP1); Goat Antigen peptide transporter 1 (TAP1) ELISA Kit; TAP1 elisa kit

• Reactivity: Goat

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Preparation and Storage: Store all reagents at 2-8 degree C.

Product Categories/Family for TAP1 elisa kit

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 9665248
• NCBI GeneID: 6890
• NCBI Accession #: NP_000584.2
• NCBI GenBank Nucleotide #: NM_000593.5
• Molecular Weight: 87,218 Da
• NCBI Official Full Name: antigen peptide transporter 1 isoform 1
• NCBI Official Synonym Full Names: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
• NCBI Official Symbol: TAP1
• NCBI Official Synonym Symbols: APT1; PSF1; ABC17; ABCB2; PSF-1; RING4; TAP1N; D6S114E; TAP1*0102N
• NCBI Protein Information: antigen peptide transporter 1; ABC transporter, MHC 1; peptide supply factor 1; peptide transporter PSF1; peptide transporter TAP1; really interesting new gene 4 protein; ATP-binding cassette sub-family B member 2; transporter associated with antigen processing; peptide transporter involved in antigen processing 1; ATP-binding cassette, sub-family B (MDR/TAP), member 2; transporter, ATP-binding cassette, major histocompatibility complex, 1
• UniProt Protein Name: Antigen peptide transporter 1
• Protein Family: Antigen peptide transporter
• UniProt Gene Name: TAP1
• UniProt Synonym Gene Names: ABCB2; PSF1; RING4; Y3; APT1; PSF-1
• UniProt Entry Name: TAP1_HUMAN

NCBI Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Uniprot Description

TAP1: a 'transporter associated with antigen processing' (TAP) protein. Member of the ATP binding cassette (ABC) family of transmembrane transporters. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. Defects in TAP1 are a cause of bare lymphocyte syndrome.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: endoplasmic reticulum membrane; TAP complex; mitochondrion; membrane; integral to membrane; integral to endoplasmic reticulum membrane

Molecular Function: protein binding; protein homodimerization activity; peptide transporter activity; TAP1 binding; peptide antigen binding; ATPase activity, coupled to transmembrane movement of substances; MHC class I protein binding; TAP2 binding; ADP binding; ATP binding; peptide-transporting ATPase activity

Biological Process: peptide transport; intracellular transport of viral proteins in host cell; antigen processing and presentation of peptide antigen via MHC class I; metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; defense response; transmembrane transport; antigen processing and presentation of endogenous peptide antigen via MHC class I; cytosol to ER transport

Disease: Bare Lymphocyte Syndrome, Type I