Guanine Nucleotide Binding Protein Alpha Inhibiting Activity 3 Recombinant Protein | GNAI3 recombinant protein

Recombinant Human Guanine Nucleotide Binding Protein Alpha Inhibiting Activity 3

Cat. Num. AAA144582

• Gene Names: GNAI3; 87U6; ARCND1
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Guanine Nucleotide Binding Protein Alpha Inhibiting Activity 3; Recombinant Human Guanine Nucleotide Binding Protein Alpha Inhibiting Activity 3; GNAI3 Human; Guanine Nucleotide Binding Protein Alpha Inhibiting Activity 3 Human Recombinant; Guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3; G(i) alpha-3; 87U6; GNAI3 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: The GNAI3 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 2mM DTT and 20% glycerol.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMGCTLSA EDKAAVERSK MIDRNLREDG EKAAKEVKLL LLGAGESGKS TIVKQMKIIH EDGYSEDECK QYKVVVYSNT IQSIIAIIRA MGRLKIDFGE AARADDARQL FVLAGSAEEG VMTPELAGVI KRLWRDGGVQ ACFSRSREYQ LNDSASYYLN DLDRISQSNY IPTQQDVLRT RVKTTGIVET HFTFKDLYFK MFDVGGQRSE RKKWIHCFEG VTAIIFCVAL SDYDLVLAED EEMNRMHESM KLFDSICNNK WFTETSIILF LNKKDLFEEK IKRSPLTICY PEYTGSNTYE EAAAYIQCQF EDLNRRKDTK EIYTHFTCAT DTKNVQFVFD AVTDVIIKNN LKECGLY
• Sequence Length: 354

Related Product Information for GNAI3 recombinant protein

Description: GNAI3 Human Recombinant produced in E Coli is a single polypeptide chain containing 377 amino acids (1-354) and having a molecular mass of 43.0kDa.GNAI3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: GNAI3 is a member of the G-alpha family and G (i/o/t/z) subfamily which act as modulators or transducers in several transmembrane signaling systems. G(k) is the stimulatory G protein of receptor-regulated K+ channels. The active GTP-bound form inhibits the connotation of RGS14 with centrosomes and is essential for the translocation of RGS14 from the cytoplasm to the plasma membrane. GNAI3 takes part in cell division and is known to cooperate with RIC8A, S1PR1, RGS5, RGS10, RGS12, RGS14, RGS16, RGS18, and RGS19.

Product Categories/Family for GNAI3 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Guanine Nucleotide Binding Protein

NCBI and Uniprot Product Information

• NCBI GI #: 5729850
• NCBI GeneID: 2773
• NCBI Accession #: NP_006487.1
• NCBI GenBank Nucleotide #: NM_006496.3
• UniProt Accession #: P08754; P17539; Q5TZX1
• Molecular Weight: 40,532 Da
• NCBI Official Full Name: guanine nucleotide-binding protein G(k) subunit alpha
• NCBI Official Synonym Full Names: guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
• NCBI Official Symbol: GNAI3
• NCBI Official Synonym Symbols: 87U6; ARCND1
• NCBI Protein Information: guanine nucleotide-binding protein G(k) subunit alpha; guanine nucleotide-binding protein G(k) subunit alpha; g(i) alpha-3
• UniProt Protein Name: Guanine nucleotide-binding protein G(k) subunit alpha
• UniProt Gene Name: GNAI3
• UniProt Entry Name: GNAI3_HUMAN

NCBI Description

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012]

Uniprot Description

G-alpha i3: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. Defects in GNAI3 are the cause of auriculocondylar syndrome 1 (ARCND1). ARCND1 is an autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia. Belongs to the G-alpha family. G(i/o/t/z) subfamily.

Protein type: G protein, heterotrimeric alpha G((i/o/t/z)); G protein; G protein, heterotrimeric

Chromosomal Location of Human Ortholog: 1p13

Cellular Component: Golgi apparatus; centrosome; membrane; lysosomal membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex; midbody; lipid raft

Molecular Function: GTPase activity; protein domain specific binding; signal transducer activity; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding; GTPase activating protein binding; metabotropic serotonin receptor binding

Biological Process: vesicle fusion; G-protein signaling, coupled to cAMP nucleotide second messenger; synaptic transmission; platelet activation; cell division; transport; metabolic process; negative regulation of adenylate cyclase activity; G-protein signaling, adenylate cyclase inhibiting pathway; cell cycle; blood coagulation

Disease: Auriculocondylar Syndrome 1