Cat Growth Hormone Antibody ELISA Kit | GH elisa kit
Cat Growth Hormone Antibody ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Function: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Subunit structure: On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain
By similarity. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation
By similarity.
Subcellular location: Cell membrane; Single-pass type I membrane protein
By similarity. Note: On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway
By similarity.Growth hormone-binding protein: Secreted
By similarity. Note: Complexed to a substantial fraction of circulating GH
By similarity.
Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The box 1 motif is required for JAK interaction and/or activation.The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization
By similarity.
Post-translational modification: On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2
By similarity. Ref.2On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization
By similarity.
Sequence similarities: Belongs to the type I cytokine receptor family. Type 1 subfamily.Contains 1 fibronectin type-III domain.