Probable serine/threonine-protein kinase GCN2 (GCN2) Recombinant Protein | GCN2 recombinant protein

Recombinant Arabidopsis thaliana Probable serine/threonine-protein kinase GCN2 (GCN2) , partial

• Gene Names: GCN2; ARABIDOPSIS THALIANA GENERAL CONTROL NON-REPRESSIBLE 2; ATGCN2; GENERAL CONTROL NON-REPRESSIBLE 2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Probable serine/threonine-protein kinase GCN2 (GCN2); Recombinant Arabidopsis thaliana Probable serine/threonine-protein kinase GCN2 (GCN2); partial; GCN2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,241

• Species: Arabidopsis thaliana (Mouse-ear cress)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 1063717712
• NCBI GeneID: 825110
• NCBI Accession #: NP_001326041.1
• NCBI GenBank Nucleotide #: NM_001339969.1
• UniProt Accession #: Q9LX30; Q8H2D3
• Molecular Weight: 140,322 Da
• NCBI Official Full Name: protein kinase family protein
• NCBI Official Symbol: GCN2
• NCBI Official Synonym Symbols: ARABIDOPSIS THALIANA GENERAL CONTROL NON-REPRESSIBLE 2; ATGCN2; GENERAL CONTROL NON-REPRESSIBLE 2
• NCBI Protein Information: protein kinase family protein
• UniProt Protein Name: eIF-2-alpha kinase GCN2
• UniProt Gene Name: GCN2

NCBI Description

Encodes an eIF2alpha kinase that can bind uncharged tRNA via its C-terminus and can phosphorylate both eIF2alpha homologues in Arabidopsis.

Uniprot Description

Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 eIF-2-alpha in response to low amino acid availability. Plays a role as an activator of the general amino acid control pathway required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha either to a competitive inhibitor of translation initiation, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, and hence allowing reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Binds uncharged tRNAs.